Trends in clinical features and survival of oral cavity cancer: Fifty years of experience with 3,362 consecutive cases from a single institution

Shu Wei Chen, Quan Zhang, Zhu Ming Guo, Wen Kuan Chen, Wei Wei Liu, Yan Feng Chen, Qiu Li Li, Xue Kui Liu, Hao Li, Dian Ou-Yang, Wei Chao Chen, Xiao Yan Fu, Xi Di Wang, An Kui Yang, Jin Xin Bei, Ming Song

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Global data demonstrate minimal improvement in the survival rate for oral cavity cancer (OCC) patients. We wished to know whether or not clinical features and survival rate have changed over time for OCC patients receiving initial treatment and follow-up at a large cancer center in China. Methods: Clinical features and survival data were collected on patients diagnosed during the successive decades of 1960–1969 (n=253), 1970–1979 (n=497), 1980–1989 (n= 659), 1990–1999 (n=793), and 2000–2009 (n=1,160) at the Sun Yat-sen University Cancer Center. Results: Over time, the overall 5-year survival rate for OCC patients was 52.0%. According to tumor localization, this rate was 71.4% for lip cancer, 56.3% for oral tongue cancer, and 42.7% for other parts of the oral cavity. From the 1960s to the 2000s, the 5-year survival rate steadily improved from 47.8% to 55.6% (P<0.001). Survival steadily decreased with age and was higher for women than for men in the 3 most recent decades. The survival rate for male patients was constant over time, while the rate for female patients improved dramatically. Obvious trends in clinical features over time included the following: increasing age of patients, increasing proportions of localized disease at diagnosis, decreasing proportions of diagnoses of lip cancer, decreasing proportions of diagnoses of squamous cell carcinoma, and decreasing proportions of non-surgical treatment approaches. Conclusion: The survival rate has steadily improved for OCC patients at this cancer center.

Original languageEnglish (US)
Pages (from-to)4523-4535
Number of pages13
JournalCancer Management and Research
Volume10
DOIs
StatePublished - Jan 1 2018

Fingerprint

Mouth Neoplasms
Mouth
Survival Rate
Lip Neoplasms
Neoplasms
Tongue Neoplasms
Survival
Solar System
Squamous Cell Carcinoma
China
Therapeutics

Keywords

  • Clinical features
  • Oral cavity cancer
  • Survival
  • Treatment modality

ASJC Scopus subject areas

  • Oncology

Cite this

Trends in clinical features and survival of oral cavity cancer : Fifty years of experience with 3,362 consecutive cases from a single institution. / Chen, Shu Wei; Zhang, Quan; Guo, Zhu Ming; Chen, Wen Kuan; Liu, Wei Wei; Chen, Yan Feng; Li, Qiu Li; Liu, Xue Kui; Li, Hao; Ou-Yang, Dian; Chen, Wei Chao; Fu, Xiao Yan; Wang, Xi Di; Yang, An Kui; Bei, Jin Xin; Song, Ming.

In: Cancer Management and Research, Vol. 10, 01.01.2018, p. 4523-4535.

Research output: Contribution to journalArticle

Chen, Shu Wei ; Zhang, Quan ; Guo, Zhu Ming ; Chen, Wen Kuan ; Liu, Wei Wei ; Chen, Yan Feng ; Li, Qiu Li ; Liu, Xue Kui ; Li, Hao ; Ou-Yang, Dian ; Chen, Wei Chao ; Fu, Xiao Yan ; Wang, Xi Di ; Yang, An Kui ; Bei, Jin Xin ; Song, Ming. / Trends in clinical features and survival of oral cavity cancer : Fifty years of experience with 3,362 consecutive cases from a single institution. In: Cancer Management and Research. 2018 ; Vol. 10. pp. 4523-4535.
@article{619030ee13ee4dc884c00c058f292319,
title = "Trends in clinical features and survival of oral cavity cancer: Fifty years of experience with 3,362 consecutive cases from a single institution",
abstract = "Background: Global data demonstrate minimal improvement in the survival rate for oral cavity cancer (OCC) patients. We wished to know whether or not clinical features and survival rate have changed over time for OCC patients receiving initial treatment and follow-up at a large cancer center in China. Methods: Clinical features and survival data were collected on patients diagnosed during the successive decades of 1960–1969 (n=253), 1970–1979 (n=497), 1980–1989 (n= 659), 1990–1999 (n=793), and 2000–2009 (n=1,160) at the Sun Yat-sen University Cancer Center. Results: Over time, the overall 5-year survival rate for OCC patients was 52.0{\%}. According to tumor localization, this rate was 71.4{\%} for lip cancer, 56.3{\%} for oral tongue cancer, and 42.7{\%} for other parts of the oral cavity. From the 1960s to the 2000s, the 5-year survival rate steadily improved from 47.8{\%} to 55.6{\%} (P<0.001). Survival steadily decreased with age and was higher for women than for men in the 3 most recent decades. The survival rate for male patients was constant over time, while the rate for female patients improved dramatically. Obvious trends in clinical features over time included the following: increasing age of patients, increasing proportions of localized disease at diagnosis, decreasing proportions of diagnoses of lip cancer, decreasing proportions of diagnoses of squamous cell carcinoma, and decreasing proportions of non-surgical treatment approaches. Conclusion: The survival rate has steadily improved for OCC patients at this cancer center.",
keywords = "Clinical features, Oral cavity cancer, Survival, Treatment modality",
author = "Chen, {Shu Wei} and Quan Zhang and Guo, {Zhu Ming} and Chen, {Wen Kuan} and Liu, {Wei Wei} and Chen, {Yan Feng} and Li, {Qiu Li} and Liu, {Xue Kui} and Hao Li and Dian Ou-Yang and Chen, {Wei Chao} and Fu, {Xiao Yan} and Wang, {Xi Di} and Yang, {An Kui} and Bei, {Jin Xin} and Ming Song",
year = "2018",
month = "1",
day = "1",
doi = "10.2147/CMAR.S171251",
language = "English (US)",
volume = "10",
pages = "4523--4535",
journal = "Cancer Management and Research",
issn = "1179-1322",
publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - Trends in clinical features and survival of oral cavity cancer

T2 - Fifty years of experience with 3,362 consecutive cases from a single institution

AU - Chen, Shu Wei

AU - Zhang, Quan

AU - Guo, Zhu Ming

AU - Chen, Wen Kuan

AU - Liu, Wei Wei

AU - Chen, Yan Feng

AU - Li, Qiu Li

AU - Liu, Xue Kui

AU - Li, Hao

AU - Ou-Yang, Dian

AU - Chen, Wei Chao

AU - Fu, Xiao Yan

AU - Wang, Xi Di

AU - Yang, An Kui

AU - Bei, Jin Xin

AU - Song, Ming

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Global data demonstrate minimal improvement in the survival rate for oral cavity cancer (OCC) patients. We wished to know whether or not clinical features and survival rate have changed over time for OCC patients receiving initial treatment and follow-up at a large cancer center in China. Methods: Clinical features and survival data were collected on patients diagnosed during the successive decades of 1960–1969 (n=253), 1970–1979 (n=497), 1980–1989 (n= 659), 1990–1999 (n=793), and 2000–2009 (n=1,160) at the Sun Yat-sen University Cancer Center. Results: Over time, the overall 5-year survival rate for OCC patients was 52.0%. According to tumor localization, this rate was 71.4% for lip cancer, 56.3% for oral tongue cancer, and 42.7% for other parts of the oral cavity. From the 1960s to the 2000s, the 5-year survival rate steadily improved from 47.8% to 55.6% (P<0.001). Survival steadily decreased with age and was higher for women than for men in the 3 most recent decades. The survival rate for male patients was constant over time, while the rate for female patients improved dramatically. Obvious trends in clinical features over time included the following: increasing age of patients, increasing proportions of localized disease at diagnosis, decreasing proportions of diagnoses of lip cancer, decreasing proportions of diagnoses of squamous cell carcinoma, and decreasing proportions of non-surgical treatment approaches. Conclusion: The survival rate has steadily improved for OCC patients at this cancer center.

AB - Background: Global data demonstrate minimal improvement in the survival rate for oral cavity cancer (OCC) patients. We wished to know whether or not clinical features and survival rate have changed over time for OCC patients receiving initial treatment and follow-up at a large cancer center in China. Methods: Clinical features and survival data were collected on patients diagnosed during the successive decades of 1960–1969 (n=253), 1970–1979 (n=497), 1980–1989 (n= 659), 1990–1999 (n=793), and 2000–2009 (n=1,160) at the Sun Yat-sen University Cancer Center. Results: Over time, the overall 5-year survival rate for OCC patients was 52.0%. According to tumor localization, this rate was 71.4% for lip cancer, 56.3% for oral tongue cancer, and 42.7% for other parts of the oral cavity. From the 1960s to the 2000s, the 5-year survival rate steadily improved from 47.8% to 55.6% (P<0.001). Survival steadily decreased with age and was higher for women than for men in the 3 most recent decades. The survival rate for male patients was constant over time, while the rate for female patients improved dramatically. Obvious trends in clinical features over time included the following: increasing age of patients, increasing proportions of localized disease at diagnosis, decreasing proportions of diagnoses of lip cancer, decreasing proportions of diagnoses of squamous cell carcinoma, and decreasing proportions of non-surgical treatment approaches. Conclusion: The survival rate has steadily improved for OCC patients at this cancer center.

KW - Clinical features

KW - Oral cavity cancer

KW - Survival

KW - Treatment modality

UR - http://www.scopus.com/inward/record.url?scp=85057601688&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057601688&partnerID=8YFLogxK

U2 - 10.2147/CMAR.S171251

DO - 10.2147/CMAR.S171251

M3 - Article

AN - SCOPUS:85057601688

VL - 10

SP - 4523

EP - 4535

JO - Cancer Management and Research

JF - Cancer Management and Research

SN - 1179-1322

ER -