Tumor microenvironment as a therapeutic target in cancer

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492 Scopus citations

Abstract

Tumor microenvironment denotes the non-cancerous cells and components presented in the tumor, including molecules produced and released by them. The constant interactions between tumor cells and the tumor microenvironment play decisive roles in tumor initiation, progression, metastasis, and response to therapies. The tumor microenvironment as a therapeutic target in cancer has attracted great research and clinical interest. Here we summarize the current progress in targeting the tumor microenvironment in both drug development and clinical trials; highlight challenges in targeting the tumor microenvironment to achieve therapeutic efficacy; explore new technologies and approaches to better decipher the tumor microenvironment; and discuss strategies to intervene in the pro-tumor microenvironment and maximize therapeutic benefits.

Original languageEnglish (US)
Article number107753
JournalPharmacology and Therapeutics
Volume221
DOIs
StatePublished - May 2021

Keywords

  • Drug
  • Resistance
  • Target
  • Therapy
  • Tumor microenvironment

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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