TY - JOUR
T1 - Tumors and mitochondrial respiration
T2 - A neglected connection
AU - Viale, Andrea
AU - Corti, Denise
AU - Draetta, Giulio F.
N1 - Publisher Copyright:
© 2015 AACR.
PY - 2015/9/15
Y1 - 2015/9/15
N2 - For decades, tumor cells have been considered defective in mitochondrial respiration due to their dominant glycolytic metabolism. However, a growing body of evidence is now challenging this assumption, and also implying that tumors are metabolically less homogeneous than previously supposed. A small subpopulation of slow-cycling cells endowed with tumorigenic potential and multidrug resistance has been isolated from different tumors. Deep metabolic characterization of these tumorigenic cells revealed their dependency on mitochondrial respiration versus glycolysis, suggesting the existence of a common metabolic program active in slowcycling cells across different tumors. These findings change our understanding of tumor metabolism and also highlight new vulnerabilities that can be exploited to eradicate cancer cells responsible for tumor relapse.
AB - For decades, tumor cells have been considered defective in mitochondrial respiration due to their dominant glycolytic metabolism. However, a growing body of evidence is now challenging this assumption, and also implying that tumors are metabolically less homogeneous than previously supposed. A small subpopulation of slow-cycling cells endowed with tumorigenic potential and multidrug resistance has been isolated from different tumors. Deep metabolic characterization of these tumorigenic cells revealed their dependency on mitochondrial respiration versus glycolysis, suggesting the existence of a common metabolic program active in slowcycling cells across different tumors. These findings change our understanding of tumor metabolism and also highlight new vulnerabilities that can be exploited to eradicate cancer cells responsible for tumor relapse.
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U2 - 10.1158/0008-5472.CAN-15-0491
DO - 10.1158/0008-5472.CAN-15-0491
M3 - Review article
C2 - 26374463
AN - SCOPUS:84942872148
SN - 0008-5472
VL - 75
SP - 3687
EP - 3691
JO - Cancer Research
JF - Cancer Research
IS - 18
ER -