Tumors and mitochondrial respiration: A neglected connection

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113 Scopus citations

Abstract

For decades, tumor cells have been considered defective in mitochondrial respiration due to their dominant glycolytic metabolism. However, a growing body of evidence is now challenging this assumption, and also implying that tumors are metabolically less homogeneous than previously supposed. A small subpopulation of slow-cycling cells endowed with tumorigenic potential and multidrug resistance has been isolated from different tumors. Deep metabolic characterization of these tumorigenic cells revealed their dependency on mitochondrial respiration versus glycolysis, suggesting the existence of a common metabolic program active in slowcycling cells across different tumors. These findings change our understanding of tumor metabolism and also highlight new vulnerabilities that can be exploited to eradicate cancer cells responsible for tumor relapse.

Original languageEnglish (US)
Pages (from-to)3687-3691
Number of pages5
JournalCancer Research
Volume75
Issue number18
DOIs
StatePublished - Sep 15 2015

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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