TY - JOUR
T1 - Two-Stage Hepatectomy for Bilateral Colorectal Liver Metastases
T2 - A Multi-institutional Analysis
AU - Chavez, Mariana I.
AU - Gholami, Sepideh
AU - Kim, Bradford J.
AU - Margonis, Georgios A.
AU - Ethun, Cecilia G.
AU - Tsai, Susan
AU - Christians, Kathleen K.
AU - Clarke, Callisia
AU - Mogal, Harveshp
AU - Maithel, Shishir K.
AU - Pawlik, Timothy M.
AU - D’Angelica, Michael I.
AU - Aloia, Thomas A.
AU - Eastwood, Daniel
AU - Gamblin, T. Clark
N1 - Publisher Copyright:
© 2021, Society of Surgical Oncology.
PY - 2021/3
Y1 - 2021/3
N2 - Background: Two-stage hepatectomy (TSH) is an important tool in the management of bilateral colorectal liver metastases (CRLM). This study sought to examine the presentation, management, and outcomes of patients completing TSH in major hepatobiliary centers in the United States (US). Methods: A retrospective review from five liver centers in the US identified patients who completed a TSH procedure for bilateral CRLM. Results: From December 2000 to March 2016, a total of 196 patients were identified. The majority of procedures were performed using an open technique (n = 194, 99.5%). The median number of tumors was 7 (range 2–33). One-hundred and twenty-eight (65.3%) patients underwent portal vein embolization. More patients received chemotherapy prior to the first stage than chemotherapy administration preceding the second stage (92% vs. 60%, p = 0.308). Median overall survival (OS) was 50 months, with a median follow-up of 28 months (range 2–143). Hepatic artery infusion chemotherapy was administered to 64 (32.7%) patients with similar OS as those managed without an infusion pump (p = 0.848). Postoperative morbidity following the second-stage resection was 47.4%. Chemotherapy prior to the second stage did not demonstrate an increased complication rate (p = 0.202). Readmission following the second stage was 10.3% and was associated with a decrease in disease-free survival (p = 0.003). OS was significantly decreased by positive resection margins and increased estimated blood loss (EBL; p = 0.036 and p = 0.05, respectively). Conclusion: This is the largest TSH series in the US and demonstrates evidence of safety and feasibility in the management of bilateral CRLM. Outcomes are influenced by margin status and operative EBL.
AB - Background: Two-stage hepatectomy (TSH) is an important tool in the management of bilateral colorectal liver metastases (CRLM). This study sought to examine the presentation, management, and outcomes of patients completing TSH in major hepatobiliary centers in the United States (US). Methods: A retrospective review from five liver centers in the US identified patients who completed a TSH procedure for bilateral CRLM. Results: From December 2000 to March 2016, a total of 196 patients were identified. The majority of procedures were performed using an open technique (n = 194, 99.5%). The median number of tumors was 7 (range 2–33). One-hundred and twenty-eight (65.3%) patients underwent portal vein embolization. More patients received chemotherapy prior to the first stage than chemotherapy administration preceding the second stage (92% vs. 60%, p = 0.308). Median overall survival (OS) was 50 months, with a median follow-up of 28 months (range 2–143). Hepatic artery infusion chemotherapy was administered to 64 (32.7%) patients with similar OS as those managed without an infusion pump (p = 0.848). Postoperative morbidity following the second-stage resection was 47.4%. Chemotherapy prior to the second stage did not demonstrate an increased complication rate (p = 0.202). Readmission following the second stage was 10.3% and was associated with a decrease in disease-free survival (p = 0.003). OS was significantly decreased by positive resection margins and increased estimated blood loss (EBL; p = 0.036 and p = 0.05, respectively). Conclusion: This is the largest TSH series in the US and demonstrates evidence of safety and feasibility in the management of bilateral CRLM. Outcomes are influenced by margin status and operative EBL.
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U2 - 10.1245/s10434-020-09459-6
DO - 10.1245/s10434-020-09459-6
M3 - Article
C2 - 33393036
AN - SCOPUS:85098739759
SN - 1068-9265
VL - 28
SP - 1457
EP - 1465
JO - Annals of surgical oncology
JF - Annals of surgical oncology
IS - 3
ER -