Type I insulin-like growth factor receptor signaling in hematological malignancies

Deeksha Vishwamitra, Suraj Konnath George, Ping Shi, Ahmed O. Kaseb, Hesham M. Amin

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

The insulin-like growth factor (IGF) signaling system plays key roles in the establishment and progression of different types of cancer. In agreement with this idea, substantial evidence has shown that the type I IGF receptor (IGF-IR) and its primary ligand IGF-I are important for maintaining the survival of malignant cells of hematopoietic origin. In this review, we discuss current understanding of the role of IGF-IR signaling in cancer with a focus on the hematological neoplasms. We also address the emergence of IGF-IR as a potential therapeutic target for the treatment of different types of cancer including plasma cell myeloma, leukemia, and lymphoma.

Original languageEnglish (US)
Pages (from-to)1814-1844
Number of pages31
JournalOncotarget
Volume8
Issue number1
DOIs
StatePublished - 2017

Keywords

  • IGF-IR
  • Leukemia
  • Lymphoma
  • Plasma cell myeloma

ASJC Scopus subject areas

  • Oncology

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