TY - JOUR
T1 - Tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia
T2 - A single-institution experience
AU - Chamoun, Kamal
AU - Kantarjian, Hagop
AU - Atallah, Rami
AU - Gonzalez, Graciela Nogueras
AU - Issa, Ghayas C.
AU - Rios, Mary Beth
AU - Garcia-Manero, Guillermo
AU - Borthakur, Gautam
AU - Ravandi, Farhad
AU - Jain, Nitin
AU - Daver, Naval
AU - Konopleva, Marina
AU - Dinardo, Courtney D.
AU - Kadia, Tapan
AU - Pemmaraju, Naveen
AU - Jabbour, Elias
AU - Cortes, Jorge E
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2019/1/3
Y1 - 2019/1/3
N2 - Background: Patients with CML treated with TKI can have a life expectancy comparable to that of the general population. Due to the extended duration of TKI administration, treatment discontinuation has been increasingly sought. Methods: Medical records of 100 patients with CML who were in MR 4.5 and discontinued their TKI outside clinical trials were reviewed. Results: After a median follow-up of 30 months (range, 5-112 months) after discontinuation, 35% and 17% lost MR 4.5 and major molecular response (MMR), respectively. Only six patients lost MMR 12 months or more after discontinuation. Loss of MR 4.5 was observed in 29% and 7% of patients with sustained MR 4.5 duration of more than 2 and 6 years before discontinuation, respectively. By univariate analysis, there was a higher risk of loss of MR 4.5 for patients who were treated for less than 87 months, received second or subsequent line TKI, never received interferon, or those with sustained MR 4.5 for less than 6 years. By multivariate analysis, sustained MR 4.5 for 6 years or more was the only significant predictor for durable response. Overall, 30% of patients who discontinued while in MR 4.5 were retreated with 93% regaining MR 4.5 at a median of 5 months. Conclusion: These results demonstrate that under proper conditions, treatment discontinuation is feasible outside of clinical trial setting. MR 4.5 duration of 6 years or more before discontinuation is associated with very low risk of loss of MR 4.5 .
AB - Background: Patients with CML treated with TKI can have a life expectancy comparable to that of the general population. Due to the extended duration of TKI administration, treatment discontinuation has been increasingly sought. Methods: Medical records of 100 patients with CML who were in MR 4.5 and discontinued their TKI outside clinical trials were reviewed. Results: After a median follow-up of 30 months (range, 5-112 months) after discontinuation, 35% and 17% lost MR 4.5 and major molecular response (MMR), respectively. Only six patients lost MMR 12 months or more after discontinuation. Loss of MR 4.5 was observed in 29% and 7% of patients with sustained MR 4.5 duration of more than 2 and 6 years before discontinuation, respectively. By univariate analysis, there was a higher risk of loss of MR 4.5 for patients who were treated for less than 87 months, received second or subsequent line TKI, never received interferon, or those with sustained MR 4.5 for less than 6 years. By multivariate analysis, sustained MR 4.5 for 6 years or more was the only significant predictor for durable response. Overall, 30% of patients who discontinued while in MR 4.5 were retreated with 93% regaining MR 4.5 at a median of 5 months. Conclusion: These results demonstrate that under proper conditions, treatment discontinuation is feasible outside of clinical trial setting. MR 4.5 duration of 6 years or more before discontinuation is associated with very low risk of loss of MR 4.5 .
KW - CML
KW - MR
KW - TKI discontinuation
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U2 - 10.1186/s13045-018-0686-1
DO - 10.1186/s13045-018-0686-1
M3 - Article
C2 - 30606227
AN - SCOPUS:85059493271
SN - 1756-8722
VL - 12
JO - Journal of Hematology and Oncology
JF - Journal of Hematology and Oncology
IS - 1
M1 - 1
ER -