Ultrasmall superparamagnetic iron oxide nanoparticles-bound NIR dyes: Novel theranostic agents for Alzheimer's disease

Jing Cai, Pascal Dao, Huixiong Chen, Longjia Yan, Yong Liang Li, Wanzheng Zhang, Li Li, Zhiyun Du, Chang Zhi Dong, Bernard Meunier

Research output: Contribution to journalArticle

Abstract

Aggregation of the β-amyloid peptide between nerve cells (neurons) in the brain leading to memory loss and progressive cognitive disability is thought to initiate Alzheimer's disease. Evidences indicate that the onset and progression of AD is associated with β-amyloid fibrillation and amyloid-related changes particularly the formation of neurotoxic oligomers may appear 10–20 years before the cognitive deficits become evident. In this study, ultrasmall superparamagnetic iron oxide nanoparticles coupled to a phenothiazine-based near-infrared (NIR) fluorescent dye have been developed and evaluated as novel theranostic agents for AD. They can simultaneously perform in vivo NIR fluorescence and magnetic resonance imaging of Aβ plaques in the brain of double transgenic mice, prevent Aβ aggregation, disaggregate preformed Aβ fibrils and play a protective effect on the toxicity of human neuroblastoma cells induced by Aβ1-42.

Original languageEnglish (US)
Article number107968
JournalDyes and Pigments
Volume173
DOIs
StatePublished - Feb 2020

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Infrared devices
Superparamagnetism
Neurodegenerative diseases
Glycoproteins
Mammals
Metal nanoparticles
Corrosion inhibitors
Iron oxides
Amyloid
Magnetic resonance imaging
Neurons
Brain
Coloring Agents
Agglomeration
Dyes
Nanoparticles
Infrared radiation
Amyloid beta-Peptides
Magnetic resonance
Fluorescent Dyes

Keywords

  • Alzheimer's disease
  • Amyloid plaques
  • Inhibitors
  • Magnetic resonance imaging
  • Near-infrared fluorescence imaging
  • Theranostic agents

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Process Chemistry and Technology

Cite this

Ultrasmall superparamagnetic iron oxide nanoparticles-bound NIR dyes : Novel theranostic agents for Alzheimer's disease. / Cai, Jing; Dao, Pascal; Chen, Huixiong; Yan, Longjia; Li, Yong Liang; Zhang, Wanzheng; Li, Li; Du, Zhiyun; Dong, Chang Zhi; Meunier, Bernard.

In: Dyes and Pigments, Vol. 173, 107968, 02.2020.

Research output: Contribution to journalArticle

Cai, Jing ; Dao, Pascal ; Chen, Huixiong ; Yan, Longjia ; Li, Yong Liang ; Zhang, Wanzheng ; Li, Li ; Du, Zhiyun ; Dong, Chang Zhi ; Meunier, Bernard. / Ultrasmall superparamagnetic iron oxide nanoparticles-bound NIR dyes : Novel theranostic agents for Alzheimer's disease. In: Dyes and Pigments. 2020 ; Vol. 173.
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abstract = "Aggregation of the β-amyloid peptide between nerve cells (neurons) in the brain leading to memory loss and progressive cognitive disability is thought to initiate Alzheimer's disease. Evidences indicate that the onset and progression of AD is associated with β-amyloid fibrillation and amyloid-related changes particularly the formation of neurotoxic oligomers may appear 10–20 years before the cognitive deficits become evident. In this study, ultrasmall superparamagnetic iron oxide nanoparticles coupled to a phenothiazine-based near-infrared (NIR) fluorescent dye have been developed and evaluated as novel theranostic agents for AD. They can simultaneously perform in vivo NIR fluorescence and magnetic resonance imaging of Aβ plaques in the brain of double transgenic mice, prevent Aβ aggregation, disaggregate preformed Aβ fibrils and play a protective effect on the toxicity of human neuroblastoma cells induced by Aβ1-42.",
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AU - Zhang, Wanzheng

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