Uncommon Cancers of the Bladder

Arlene O. Siefker-Radtke; Bogdan A. Czerniak; Colin P. Dinney; Randall E. Millikan

doi:10.1002/9781118464557.ch2

Uncommon Cancers of the Bladder

Arlene O. Siefker-Radtke, Bogdan A. Czerniak, Colin P. Dinney, Randall E. Millikan

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Micropapillary, sarcomatoid, and small cell carcinoma are uncommon, aggressive variants usually encountered in the evolution of high-grade nonpapillary transitional cell carcinoma. Of these, only small cell is effectively treated with currently available systemic therapy, with recent evidence suggesting a role for neoadjuvant chemotherapy. While adenocarcinoma and squamous cancers can also arise from the urothelium, neither is as sensitive to chemotherapy as conventional transitional cell carcinoma. Dominant lymphoepithelioma has a favorable prognosis. Urachal cancers require preoperative recognition for optimal surgical management, and are being shown to be somewhat responsive to regimens useful in colon cancer. Mesenchymal tumors are exceedingly rare and are treated like other pelvic sarcomas.

Original language	English (US)
Title of host publication	Textbook of Uncommon Cancer
Publisher	John Wiley and Sons
Pages	23-33
Number of pages	11
ISBN (Print)	9781118083734
DOIs	https://doi.org/10.1002/9781118464557.ch2
State	Published - Sep 20 2012

Keywords

Lymphoepithelioma
Micropapillary
Sarcomatoid
Small cell
Urachal
Urothelium

ASJC Scopus subject areas

General Medicine

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10.1002/9781118464557.ch2

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title = "Uncommon Cancers of the Bladder",

abstract = "Micropapillary, sarcomatoid, and small cell carcinoma are uncommon, aggressive variants usually encountered in the evolution of high-grade nonpapillary transitional cell carcinoma. Of these, only small cell is effectively treated with currently available systemic therapy, with recent evidence suggesting a role for neoadjuvant chemotherapy. While adenocarcinoma and squamous cancers can also arise from the urothelium, neither is as sensitive to chemotherapy as conventional transitional cell carcinoma. Dominant lymphoepithelioma has a favorable prognosis. Urachal cancers require preoperative recognition for optimal surgical management, and are being shown to be somewhat responsive to regimens useful in colon cancer. Mesenchymal tumors are exceedingly rare and are treated like other pelvic sarcomas.",

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AU - Siefker-Radtke, Arlene O.

AU - Czerniak, Bogdan A.

AU - Dinney, Colin P.

AU - Millikan, Randall E.

PY - 2012/9/20

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AB - Micropapillary, sarcomatoid, and small cell carcinoma are uncommon, aggressive variants usually encountered in the evolution of high-grade nonpapillary transitional cell carcinoma. Of these, only small cell is effectively treated with currently available systemic therapy, with recent evidence suggesting a role for neoadjuvant chemotherapy. While adenocarcinoma and squamous cancers can also arise from the urothelium, neither is as sensitive to chemotherapy as conventional transitional cell carcinoma. Dominant lymphoepithelioma has a favorable prognosis. Urachal cancers require preoperative recognition for optimal surgical management, and are being shown to be somewhat responsive to regimens useful in colon cancer. Mesenchymal tumors are exceedingly rare and are treated like other pelvic sarcomas.

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KW - Sarcomatoid

KW - Small cell

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KW - Urothelium

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Uncommon Cancers of the Bladder

Abstract

Keywords

ASJC Scopus subject areas

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