Unfolding the secrets of small cell lung cancer progression: Novel approaches and insights through rapid autopsies

Zsolt Megyesfalvi; Simon Heeke; Benjamin J. Drapkin; Anna Solta; Ildiko Kovacs; Kristiina Boettiger; Lilla Horvath; Busra Ernhofer; Janos Fillinger; Ferenc Renyi-Vamos; Clemens Aigner; Karin Schelch; Christian Lang; Gyorgy Marko-Varga; Carl M. Gay; Lauren A. Byers; Benjamin B. Morris; John V. Heymach; Peter Van Loo; Fred R. Hirsch; Balazs Dome

doi:10.1016/j.ccell.2023.08.007

Unfolding the secrets of small cell lung cancer progression: Novel approaches and insights through rapid autopsies

Zsolt Megyesfalvi
, Simon Heeke
, Benjamin J. Drapkin
, Anna Solta
, Ildiko Kovacs
, Kristiina Boettiger
, Lilla Horvath
, Busra Ernhofer
, Janos Fillinger
, Ferenc Renyi-Vamos
, Clemens Aigner
, Karin Schelch
, Christian Lang
, Gyorgy Marko-Varga
, Carl M. Gay
, Lauren A. Byers
, Benjamin B. Morris
, John V. Heymach
, Peter Van Loo
, Fred R. Hirsch

Balazs Dome

Research output: Contribution to journal › Comment/debate › peer-review

7 Scopus citations

Abstract

The understanding of small cell lung cancer (SCLC) biology has increased dramatically in recent years, but the processes that allow SCLC to progress rapidly remain poorly understood. Here, we advocate the integration of rapid autopsies and preclinical models into SCLC research as a comprehensive strategy with the potential to revolutionize current treatment paradigms.

Original language	English (US)
Pages (from-to)	1535-1540
Number of pages	6
Journal	Cancer cell
Volume	41
Issue number	9
DOIs	https://doi.org/10.1016/j.ccell.2023.08.007
State	Published - Sep 11 2023

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.ccell.2023.08.007

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Megyesfalvi, Z., Heeke, S., Drapkin, B. J., Solta, A., Kovacs, I., Boettiger, K., Horvath, L., Ernhofer, B., Fillinger, J., Renyi-Vamos, F., Aigner, C., Schelch, K., Lang, C., Marko-Varga, G., Gay, C. M., Byers, L. A., Morris, B. B., Heymach, J. V., Van Loo, P., ... Dome, B. (2023). Unfolding the secrets of small cell lung cancer progression: Novel approaches and insights through rapid autopsies. Cancer cell, 41(9), 1535-1540. https://doi.org/10.1016/j.ccell.2023.08.007

Megyesfalvi, Z, Heeke, S, Drapkin, BJ, Solta, A, Kovacs, I, Boettiger, K, Horvath, L, Ernhofer, B, Fillinger, J, Renyi-Vamos, F, Aigner, C, Schelch, K, Lang, C, Marko-Varga, G, Gay, CM , Byers, LA, Morris, BB, Heymach, JV , Van Loo, P, Hirsch, FR & Dome, B 2023, 'Unfolding the secrets of small cell lung cancer progression: Novel approaches and insights through rapid autopsies', Cancer cell, vol. 41, no. 9, pp. 1535-1540. https://doi.org/10.1016/j.ccell.2023.08.007

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title = "Unfolding the secrets of small cell lung cancer progression: Novel approaches and insights through rapid autopsies",

abstract = "The understanding of small cell lung cancer (SCLC) biology has increased dramatically in recent years, but the processes that allow SCLC to progress rapidly remain poorly understood. Here, we advocate the integration of rapid autopsies and preclinical models into SCLC research as a comprehensive strategy with the potential to revolutionize current treatment paradigms.",

author = "Zsolt Megyesfalvi and Simon Heeke and Drapkin, \{Benjamin J.\} and Anna Solta and Ildiko Kovacs and Kristiina Boettiger and Lilla Horvath and Busra Ernhofer and Janos Fillinger and Ferenc Renyi-Vamos and Clemens Aigner and Karin Schelch and Christian Lang and Gyorgy Marko-Varga and Gay, \{Carl M.\} and Byers, \{Lauren A.\} and Morris, \{Benjamin B.\} and Heymach, \{John V.\} and \{Van Loo\}, Peter and Hirsch, \{Fred R.\} and Balazs Dome",

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year = "2023",

month = sep,

day = "11",

doi = "10.1016/j.ccell.2023.08.007",

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TY - JOUR

T1 - Unfolding the secrets of small cell lung cancer progression

T2 - Novel approaches and insights through rapid autopsies

AU - Megyesfalvi, Zsolt

AU - Heeke, Simon

AU - Drapkin, Benjamin J.

AU - Solta, Anna

AU - Kovacs, Ildiko

AU - Boettiger, Kristiina

AU - Horvath, Lilla

AU - Ernhofer, Busra

AU - Fillinger, Janos

AU - Renyi-Vamos, Ferenc

AU - Aigner, Clemens

AU - Schelch, Karin

AU - Lang, Christian

AU - Marko-Varga, Gyorgy

AU - Gay, Carl M.

AU - Byers, Lauren A.

AU - Morris, Benjamin B.

AU - Heymach, John V.

AU - Van Loo, Peter

AU - Hirsch, Fred R.

AU - Dome, Balazs

PY - 2023/9/11

Y1 - 2023/9/11

N2 - The understanding of small cell lung cancer (SCLC) biology has increased dramatically in recent years, but the processes that allow SCLC to progress rapidly remain poorly understood. Here, we advocate the integration of rapid autopsies and preclinical models into SCLC research as a comprehensive strategy with the potential to revolutionize current treatment paradigms.

AB - The understanding of small cell lung cancer (SCLC) biology has increased dramatically in recent years, but the processes that allow SCLC to progress rapidly remain poorly understood. Here, we advocate the integration of rapid autopsies and preclinical models into SCLC research as a comprehensive strategy with the potential to revolutionize current treatment paradigms.

UR - https://www.scopus.com/pages/publications/85169512155

UR - https://www.scopus.com/pages/publications/85169512155#tab=citedBy

U2 - 10.1016/j.ccell.2023.08.007

DO - 10.1016/j.ccell.2023.08.007

M3 - Comment/debate

C2 - 37699331

AN - SCOPUS:85169512155

SN - 1535-6108

VL - 41

SP - 1535

EP - 1540

JO - Cancer cell

JF - Cancer cell

IS - 9

ER -

Unfolding the secrets of small cell lung cancer progression: Novel approaches and insights through rapid autopsies

Abstract

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