Abstract
Myeloproliferative neoplasms (MPNs) are clonal disorders divided into Philadelphia (Ph) chromosome-positive chronic myeloid leukemia (CML) or Ph chromosome-negative MPNs. Co-occurrence of these disease entities is very rare and typically involves presence of common p190 or p210 BCR/ABL fusion transcript (responsible for CML) along with JAK2 V617F mutation (most common driver mutation in Ph-negative MPNs). Because of the rarity of such cases, it is not clear if the outcomes are any different in these patients. In this article, we report a unique patient with polycythemia vera driven by a rare complex in-frame deletion-insertion mutation in JAK2 exon 12, and CML driven by uncommon p210 e14a3 (b3a3) BCR/ABL fusion transcript. We describe clinical and laboratory features, bone marrow pathology, treatment, and overall outcome.
Original language | English (US) |
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Pages (from-to) | 23-27 |
Number of pages | 5 |
Journal | Acta haematologica |
Volume | 141 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2019 |
Keywords
- JAK2 exon 12 mutation
- Myeloproliferative neoplasm
- Philadelphia chromosome-positive chronic myeloid leukemia
- p210 e14a3 BCR/ABL fusion transcript
ASJC Scopus subject areas
- Hematology