Unraveling the therapeutic potential of the LncRNA-dependent noncanonical Hedgehog pathway in cancer

Zhen Xing; Chunru Lin; Liuqing Yang

doi:10.1080/23723556.2014.998900

Unraveling the therapeutic potential of the LncRNA-dependent noncanonical Hedgehog pathway in cancer

Zhen Xing, Chunru Lin, Liuqing Yang

Molecular & Cellular Oncology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Acquired resistance to Hedgehog pathway inhibitors has been reported in the clinical setting and upregulation of noncanonical Hedgehog signaling is one of the major underlying mechanisms behind this resistance. As demonstrated in our recent study, greater clinical efficacy might be achieved by focusing on downstream targets of the chemokine-activated noncanonical Hedgehog signaling pathway such as BCAR4 and phospho-GLI2 (Ser149).

Original language	English (US)
Article number	e998900
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	4
DOIs	https://doi.org/10.1080/23723556.2014.998900
State	Published - Oct 2 2015

Keywords

BCAR4
Hedgehog Gli2
Long non-coding RNA
breast cancer
cancer treatment
locked nucleic acid
lung metastasis
signaling pathway

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.1080/23723556.2014.998900

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title = "Unraveling the therapeutic potential of the LncRNA-dependent noncanonical Hedgehog pathway in cancer",

abstract = "Acquired resistance to Hedgehog pathway inhibitors has been reported in the clinical setting and upregulation of noncanonical Hedgehog signaling is one of the major underlying mechanisms behind this resistance. As demonstrated in our recent study, greater clinical efficacy might be achieved by focusing on downstream targets of the chemokine-activated noncanonical Hedgehog signaling pathway such as BCAR4 and phospho-GLI2 (Ser149).",

keywords = "BCAR4, Hedgehog Gli2, Long non-coding RNA, breast cancer, cancer treatment, locked nucleic acid, lung metastasis, signaling pathway",

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AB - Acquired resistance to Hedgehog pathway inhibitors has been reported in the clinical setting and upregulation of noncanonical Hedgehog signaling is one of the major underlying mechanisms behind this resistance. As demonstrated in our recent study, greater clinical efficacy might be achieved by focusing on downstream targets of the chemokine-activated noncanonical Hedgehog signaling pathway such as BCAR4 and phospho-GLI2 (Ser149).

KW - BCAR4

KW - Hedgehog Gli2

KW - Long non-coding RNA

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KW - cancer treatment

KW - locked nucleic acid

KW - lung metastasis

KW - signaling pathway

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Unraveling the therapeutic potential of the LncRNA-dependent noncanonical Hedgehog pathway in cancer

Abstract

Keywords

ASJC Scopus subject areas

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