TY - JOUR
T1 - Update on cannabis and cannabinoids for cancer pain
AU - Chung, Matthew
AU - Kim, Hee Kee
AU - Abdi, Salahadin
N1 - Funding Information:
This work was supported by grants from the Helen Buchanan and Stanley Joseph Seeger Endowment at The University of Texas MD Anderson Cancer Center to S.A.
Publisher Copyright:
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.,cancer pain, cannabinoids, cannabis.
PY - 2020/12
Y1 - 2020/12
N2 - Purpose of review The prevalence of cancer pain will continue to rise as pain is common among the survivorship and general cancer population. As interest in cannabis and cannabinoids for medicinal use including pain management continues to rise, there is growing need to update and review the current state of evidence for their use. The literature was searched for articles in English with key words cannabis, cannabinoids, and cancer pain. The sources of articles were PubMed, Embase, and open Google search. Recent findings In a double-blind randomized placebo-controlled trial including a 3-week treatment period of nabiximol for advanced cancer patients with pain refractory to optimized opiate therapy, improvements in average pain were seen in the intention to treat population (PÂ0.0854) and per-protocol population (PÂ0.0378). Summary To date, preclinical data has demonstrated evidence to suggest promising potential for cancer pain and the urgent need to translate this into clinical practice. Unfortunately, due to limited data, for adults with advanced cancer being treated with opiate therapy, the addition of cannabis or cannabinoids is not currently supported to address cancer pain effectively.
AB - Purpose of review The prevalence of cancer pain will continue to rise as pain is common among the survivorship and general cancer population. As interest in cannabis and cannabinoids for medicinal use including pain management continues to rise, there is growing need to update and review the current state of evidence for their use. The literature was searched for articles in English with key words cannabis, cannabinoids, and cancer pain. The sources of articles were PubMed, Embase, and open Google search. Recent findings In a double-blind randomized placebo-controlled trial including a 3-week treatment period of nabiximol for advanced cancer patients with pain refractory to optimized opiate therapy, improvements in average pain were seen in the intention to treat population (PÂ0.0854) and per-protocol population (PÂ0.0378). Summary To date, preclinical data has demonstrated evidence to suggest promising potential for cancer pain and the urgent need to translate this into clinical practice. Unfortunately, due to limited data, for adults with advanced cancer being treated with opiate therapy, the addition of cannabis or cannabinoids is not currently supported to address cancer pain effectively.
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U2 - 10.1097/ACO.0000000000000934
DO - 10.1097/ACO.0000000000000934
M3 - Review article
C2 - 33110020
AN - SCOPUS:85094820347
SN - 0952-7907
VL - 33
SP - 825
EP - 831
JO - Current opinion in anaesthesiology
JF - Current opinion in anaesthesiology
IS - 6
ER -