TY - JOUR
T1 - Updates on Conservative Management of Endometrial Cancer
AU - Corzo, Camila
AU - Barrientos Santillan, Natalia
AU - Westin, Shannon N.
AU - Ramirez, Pedro T.
N1 - Funding Information:
Dr. Westin has research funding from Novartis, AstraZeneca, and Critical Outcomes Technologies, Inc., and has received consulting fees from AstraZeneca, Clovis, Roche/Genentech, Casdin Capital, Ovation, Vermilion, and Medivation.
Publisher Copyright:
© 2017 American Association of Gynecologic Laparoscopists
PY - 2018/2
Y1 - 2018/2
N2 - Endometrial cancer is the most common gynecologic cancer in the United States. It is typically diagnosed in postmenopausal women. However, given the increasing incidence of risk factors such as obesity and diabetes in younger women, it is becoming a more prevalent problem in this age group. When endometrial cancer is diagnosed in patients of reproductive age, the standard surgical option of hysterectomy and bilateral salpingo-oophorectomy may not be ideal for women interested in future fertility. Hence, conservative options for select patients should be discussed along with the associated outcomes of each approach. A number of studies have shown that in patients with complex atypical endometrial hyperplasia and grade I endometrial carcinoma, a conservative approach is safe and feasible. The aim of this review is to summarize published evidence of fertility-sparing options such as hormonal therapy, hysteroscopic resection of focal lesions, and the role of intrauterine devices. We will also provide the latest updates on ongoing prospective trials that explore strategies for conservative management in women with medical comorbidities or those interested in fertility preservation.
AB - Endometrial cancer is the most common gynecologic cancer in the United States. It is typically diagnosed in postmenopausal women. However, given the increasing incidence of risk factors such as obesity and diabetes in younger women, it is becoming a more prevalent problem in this age group. When endometrial cancer is diagnosed in patients of reproductive age, the standard surgical option of hysterectomy and bilateral salpingo-oophorectomy may not be ideal for women interested in future fertility. Hence, conservative options for select patients should be discussed along with the associated outcomes of each approach. A number of studies have shown that in patients with complex atypical endometrial hyperplasia and grade I endometrial carcinoma, a conservative approach is safe and feasible. The aim of this review is to summarize published evidence of fertility-sparing options such as hormonal therapy, hysteroscopic resection of focal lesions, and the role of intrauterine devices. We will also provide the latest updates on ongoing prospective trials that explore strategies for conservative management in women with medical comorbidities or those interested in fertility preservation.
KW - Conservative therapy
KW - Progestin therapy
KW - Uterine cancer
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U2 - 10.1016/j.jmig.2017.07.022
DO - 10.1016/j.jmig.2017.07.022
M3 - Review article
C2 - 28782618
AN - SCOPUS:85028604318
SN - 1553-4650
VL - 25
SP - 308
EP - 313
JO - Journal of Minimally Invasive Gynecology
JF - Journal of Minimally Invasive Gynecology
IS - 2
ER -