Use of ceftolozane/tazobactam in the treatment of multidrug-resistant pseudomonas aeruginosa bloodstream infection in a pediatric leukemia patient

Samuel L. Aitken; Dimitrios P. Kontoyiannis; April M. Depombo; Micah M. Bhatti; Frank P. Tverdek; Suzanne C. Gettys; David P. Nicolau; Cesar A. Nunez

doi:10.1097/INF.0000000000001228

Use of ceftolozane/tazobactam in the treatment of multidrug-resistant pseudomonas aeruginosa bloodstream infection in a pediatric leukemia patient

Samuel L. Aitken, Dimitrios P. Kontoyiannis, April M. Depombo, Micah M. Bhatti, Frank P. Tverdek, Suzanne C. Gettys, David P. Nicolau, Cesar A. Nunez

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Multidrug-resistant Pseudomonas aeruginosa is of increasing concern in pediatric patients. Ceftolozane/tazobactam is a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant Pseudomonas; however, no data exist on its use in children. This report summarizes the treatment of a multidrug-resistant P. aeruginosa bloodstream infection in a pediatric leukemia patient with ceftolozane/tazobactam and provides the first description of its pharmacokinetics in pediatrics.

Original language	English (US)
Pages (from-to)	1040-1042
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	35
Issue number	9
DOIs	https://doi.org/10.1097/INF.0000000000001228
State	Published - Sep 1 2016

Keywords

bloodstream infection
cancer
extended infusion
febrile neutropenia
pharmacokinetics

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

Access to Document

10.1097/INF.0000000000001228

Cite this

Aitken, S. L., Kontoyiannis, D. P., Depombo, A. M., Bhatti, M. M., Tverdek, F. P., Gettys, S. C., Nicolau, D. P., & Nunez, C. A. (2016). Use of ceftolozane/tazobactam in the treatment of multidrug-resistant pseudomonas aeruginosa bloodstream infection in a pediatric leukemia patient. Pediatric Infectious Disease Journal, 35(9), 1040-1042. https://doi.org/10.1097/INF.0000000000001228

Use of ceftolozane/tazobactam in the treatment of multidrug-resistant pseudomonas aeruginosa bloodstream infection in a pediatric leukemia patient. / Aitken, Samuel L.; Kontoyiannis, Dimitrios P.; Depombo, April M. et al.
In: Pediatric Infectious Disease Journal, Vol. 35, No. 9, 01.09.2016, p. 1040-1042.

Research output: Contribution to journal › Article › peer-review

Aitken, SL, Kontoyiannis, DP, Depombo, AM, Bhatti, MM, Tverdek, FP, Gettys, SC, Nicolau, DP & Nunez, CA 2016, 'Use of ceftolozane/tazobactam in the treatment of multidrug-resistant pseudomonas aeruginosa bloodstream infection in a pediatric leukemia patient', Pediatric Infectious Disease Journal, vol. 35, no. 9, pp. 1040-1042. https://doi.org/10.1097/INF.0000000000001228

@article{e20290b157c9461d8710573dbfd9ab72,

title = "Use of ceftolozane/tazobactam in the treatment of multidrug-resistant pseudomonas aeruginosa bloodstream infection in a pediatric leukemia patient",

abstract = "Multidrug-resistant Pseudomonas aeruginosa is of increasing concern in pediatric patients. Ceftolozane/tazobactam is a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant Pseudomonas; however, no data exist on its use in children. This report summarizes the treatment of a multidrug-resistant P. aeruginosa bloodstream infection in a pediatric leukemia patient with ceftolozane/tazobactam and provides the first description of its pharmacokinetics in pediatrics.",

keywords = "bloodstream infection, cancer, extended infusion, febrile neutropenia, pharmacokinetics",

author = "Aitken, {Samuel L.} and Kontoyiannis, {Dimitrios P.} and Depombo, {April M.} and Bhatti, {Micah M.} and Tverdek, {Frank P.} and Gettys, {Suzanne C.} and Nicolau, {David P.} and Nunez, {Cesar A.}",

note = "Publisher Copyright: {\textcopyright} 2016 Wolters Kluwer Health, Inc.",

year = "2016",

month = sep,

day = "1",

doi = "10.1097/INF.0000000000001228",

language = "English (US)",

volume = "35",

pages = "1040--1042",

journal = "Pediatric Infectious Disease Journal",

issn = "0891-3668",

publisher = "Lippincott Williams and Wilkins",

number = "9",

}

TY - JOUR

T1 - Use of ceftolozane/tazobactam in the treatment of multidrug-resistant pseudomonas aeruginosa bloodstream infection in a pediatric leukemia patient

AU - Aitken, Samuel L.

AU - Kontoyiannis, Dimitrios P.

AU - Depombo, April M.

AU - Bhatti, Micah M.

AU - Tverdek, Frank P.

AU - Gettys, Suzanne C.

AU - Nicolau, David P.

AU - Nunez, Cesar A.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Multidrug-resistant Pseudomonas aeruginosa is of increasing concern in pediatric patients. Ceftolozane/tazobactam is a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant Pseudomonas; however, no data exist on its use in children. This report summarizes the treatment of a multidrug-resistant P. aeruginosa bloodstream infection in a pediatric leukemia patient with ceftolozane/tazobactam and provides the first description of its pharmacokinetics in pediatrics.

AB - Multidrug-resistant Pseudomonas aeruginosa is of increasing concern in pediatric patients. Ceftolozane/tazobactam is a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant Pseudomonas; however, no data exist on its use in children. This report summarizes the treatment of a multidrug-resistant P. aeruginosa bloodstream infection in a pediatric leukemia patient with ceftolozane/tazobactam and provides the first description of its pharmacokinetics in pediatrics.

KW - bloodstream infection

KW - cancer

KW - extended infusion

KW - febrile neutropenia

KW - pharmacokinetics

UR - http://www.scopus.com/inward/record.url?scp=84973151729&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84973151729&partnerID=8YFLogxK

U2 - 10.1097/INF.0000000000001228

DO - 10.1097/INF.0000000000001228

M3 - Article

C2 - 27254038

AN - SCOPUS:84973151729

SN - 0891-3668

VL - 35

SP - 1040

EP - 1042

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 9

ER -

Use of ceftolozane/tazobactam in the treatment of multidrug-resistant pseudomonas aeruginosa bloodstream infection in a pediatric leukemia patient

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this