Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses

Cristina Parolin; Alessandra Borsetti; Hyeryun Choe; Michael Farzan; Peter Kolchinsky; Michael Heesen; Qing Ma; Craig Gerard; Giorgio Palu; Martin E. Dorf; Timothy Springer; Joseph Sodroski

doi:10.1128/jvi.72.2.1652-1656.1998

Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses

Cristina Parolin, Alessandra Borsetti, Hyeryun Choe, Michael Farzan, Peter Kolchinsky, Michael Heesen, Qing Ma, Craig Gerard, Giorgio Palu, Martin E. Dorf, Timothy Springer, Joseph Sodroski

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The human CXCR-4 molecule serves as a second receptor for primary, T- cell-tropic, and laboratory-adapted human immunodeficiency virus type 1 (HIV- 1) isolates. Here we show that murine CXCR-4 can support the entry of some of these HIV-1 isolates. Differences between mouse and human CXCR-4 in the ability to function as an HIV-1 receptor are determined by sequences in the second extracellular loop of the CXCR-4 protein.

Original language	English (US)
Pages (from-to)	1652-1656
Number of pages	5
Journal	Journal of Virology
Volume	72
Issue number	2
DOIs	https://doi.org/10.1128/jvi.72.2.1652-1656.1998
State	Published - Feb 1998
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/jvi.72.2.1652-1656.1998

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abstract = "The human CXCR-4 molecule serves as a second receptor for primary, T- cell-tropic, and laboratory-adapted human immunodeficiency virus type 1 (HIV- 1) isolates. Here we show that murine CXCR-4 can support the entry of some of these HIV-1 isolates. Differences between mouse and human CXCR-4 in the ability to function as an HIV-1 receptor are determined by sequences in the second extracellular loop of the CXCR-4 protein.",

author = "Cristina Parolin and Alessandra Borsetti and Hyeryun Choe and Michael Farzan and Peter Kolchinsky and Michael Heesen and Qing Ma and Craig Gerard and Giorgio Palu and Dorf, {Martin E.} and Timothy Springer and Joseph Sodroski",

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AU - Parolin, Cristina

AU - Borsetti, Alessandra

AU - Choe, Hyeryun

AU - Farzan, Michael

AU - Kolchinsky, Peter

AU - Heesen, Michael

AU - Ma, Qing

AU - Gerard, Craig

AU - Palu, Giorgio

AU - Dorf, Martin E.

AU - Springer, Timothy

AU - Sodroski, Joseph

PY - 1998/2

Y1 - 1998/2

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AB - The human CXCR-4 molecule serves as a second receptor for primary, T- cell-tropic, and laboratory-adapted human immunodeficiency virus type 1 (HIV- 1) isolates. Here we show that murine CXCR-4 can support the entry of some of these HIV-1 isolates. Differences between mouse and human CXCR-4 in the ability to function as an HIV-1 receptor are determined by sequences in the second extracellular loop of the CXCR-4 protein.

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Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses

Abstract

ASJC Scopus subject areas

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