Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses

Cristina Parolin; Alessandra Borsetti; Hyeryun Choe; Michael Farzan; Peter Kolchinsky; Michael Heesen; Qing Ma; Craig Gerard; Giorgio Palu; Martin E. Dorf; Timothy Springer; Joseph Sodroski

doi:10.1128/jvi.72.2.1652-1656.1998

Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses

Cristina Parolin
, Alessandra Borsetti
, Hyeryun Choe
, Michael Farzan
, Peter Kolchinsky
, Michael Heesen
, Qing Ma
, Craig Gerard
, Giorgio Palu
, Martin E. Dorf
, Timothy Springer
, Joseph Sodroski

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The human CXCR-4 molecule serves as a second receptor for primary, T- cell-tropic, and laboratory-adapted human immunodeficiency virus type 1 (HIV- 1) isolates. Here we show that murine CXCR-4 can support the entry of some of these HIV-1 isolates. Differences between mouse and human CXCR-4 in the ability to function as an HIV-1 receptor are determined by sequences in the second extracellular loop of the CXCR-4 protein.

Original language	English (US)
Pages (from-to)	1652-1656
Number of pages	5
Journal	Journal of Virology
Volume	72
Issue number	2
DOIs	https://doi.org/10.1128/jvi.72.2.1652-1656.1998
State	Published - Feb 1998
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/jvi.72.2.1652-1656.1998

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title = "Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses",

abstract = "The human CXCR-4 molecule serves as a second receptor for primary, T- cell-tropic, and laboratory-adapted human immunodeficiency virus type 1 (HIV- 1) isolates. Here we show that murine CXCR-4 can support the entry of some of these HIV-1 isolates. Differences between mouse and human CXCR-4 in the ability to function as an HIV-1 receptor are determined by sequences in the second extracellular loop of the CXCR-4 protein.",

author = "Cristina Parolin and Alessandra Borsetti and Hyeryun Choe and Michael Farzan and Peter Kolchinsky and Michael Heesen and Qing Ma and Craig Gerard and Giorgio Palu and Dorf, \{Martin E.\} and Timothy Springer and Joseph Sodroski",

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T1 - Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses

AU - Parolin, Cristina

AU - Borsetti, Alessandra

AU - Choe, Hyeryun

AU - Farzan, Michael

AU - Kolchinsky, Peter

AU - Heesen, Michael

AU - Ma, Qing

AU - Gerard, Craig

AU - Palu, Giorgio

AU - Dorf, Martin E.

AU - Springer, Timothy

AU - Sodroski, Joseph

PY - 1998/2

Y1 - 1998/2

N2 - The human CXCR-4 molecule serves as a second receptor for primary, T- cell-tropic, and laboratory-adapted human immunodeficiency virus type 1 (HIV- 1) isolates. Here we show that murine CXCR-4 can support the entry of some of these HIV-1 isolates. Differences between mouse and human CXCR-4 in the ability to function as an HIV-1 receptor are determined by sequences in the second extracellular loop of the CXCR-4 protein.

AB - The human CXCR-4 molecule serves as a second receptor for primary, T- cell-tropic, and laboratory-adapted human immunodeficiency virus type 1 (HIV- 1) isolates. Here we show that murine CXCR-4 can support the entry of some of these HIV-1 isolates. Differences between mouse and human CXCR-4 in the ability to function as an HIV-1 receptor are determined by sequences in the second extracellular loop of the CXCR-4 protein.

UR - https://www.scopus.com/pages/publications/0031883440

UR - https://www.scopus.com/pages/publications/0031883440#tab=citedBy

U2 - 10.1128/jvi.72.2.1652-1656.1998

DO - 10.1128/jvi.72.2.1652-1656.1998

M3 - Article

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AN - SCOPUS:0031883440

SN - 0022-538X

VL - 72

SP - 1652

EP - 1656

JO - Journal of Virology

JF - Journal of Virology

IS - 2

ER -

Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses

Abstract

ASJC Scopus subject areas

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