@inbook{54c8d6df2f8249a583d1fe1e92b365f1,
title = "Use of tyrosine kinase inhibitors for treatment of medullary thyroid carcinoma",
abstract = "Two independent events-the identification of activating mutations of the RET proto-oncogene, a receptor tyrosine kinase, in medullary thyroid carcinoma, and the recognition that small organic molecules could bind to and inhibit phosphorylation of signaling molecules, thereby inactivating the pathway-led to the recognition that kinase inhibitors could be used to treat medullary thyroid carcinoma (MTC). The introduction of these compounds into clinical practice has transformed the treatment of metastatic MTC and provided insight into the mechanisms by which RET causes C-cell transformation. This chapter will review the progress in this field over the past 7 years.",
keywords = "Cabozantinib, Calcitonin, Medullary thyroid carcinoma, Metastasis, Multiple endocrine neoplasia type 2, RET proto-oncogene, Tyrosine kinase inhibitor, Vandetanib",
author = "Ramona Dadu and Hu, {Mimi N.} and Grubbs, {Elizabeth G.} and Gagel, {Robert F.}",
note = "Publisher Copyright: {\textcopyright} Springer International Publishing Switzerland 2015.",
year = "2015",
doi = "10.1007/978-3-319-22542-5_11",
language = "English (US)",
series = "Recent Results in Cancer Research",
publisher = "Springer New York LLC",
pages = "227--249",
booktitle = "Recent Results in Cancer Research",
}