Vagotomy blocks behavioural effects of interleukin-1 injected via the intraperitoneal route but not via other systemic routes

Rose Marie Bluthé, Bruno Michaud, Keith W. Kelley, Robert Dantzer

Research output: Contribution to journalArticle

117 Scopus citations


To test specificity of the involvement of vagal afferents in the communication between the immune system and the brain, sham-operated and vagotomized mice were injected i.p., s.c. or i.v. with physiological saline or interleukin-1β (IL-1β) 4 weeks after surgery. Vagotomy attenuated the decrease in social exploration induced by i.p. injection of 300 ng recombinant human IL-1β but had no effect when IL-1β was injected s.c. (300 ng) or i.v. (500 ng). Vagotomy also attenuated the depression in social investigation induced by i.p. injection of recombinant rat IL-1β (IL-1β, 1 μg) but was without effect when 1 μg IL-1β was injected i.v. These results confirm the role of vagal afferent nerves in the transmission of an immune message from the periphery to the brain and show that the vagus nerve only conveys information concerning cytokines injected into the abdominal cavity.

Original languageEnglish (US)
Pages (from-to)2823-2827
Number of pages5
Issue number15-17
StatePublished - Jan 1 1996



  • Behaviour
  • Cytokine
  • Interleukin-1β
  • Mouse
  • Route of injection
  • Vagus nerve

ASJC Scopus subject areas

  • Neuroscience(all)

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