Villoglandular papillary adenocarcinoma of the cervix a series of 28 cases including two with lymph node metastasis

Isam M. Lataifeh, Maysa Al-Hussaini, Catherine Uzan, Imad Jaradat, Pierre Duvillard, Philippe Morice

    Research output: Contribution to journalReview article

    13 Scopus citations

    Abstract

    Objective: To investigate the clinicopathologic features, the management, and the outcome of villoglandular papillary adenocarcinoma (VGPA) of the uterine cervix. Methods: A retrospective review of patients' clinical characteristics, pathology, and the disease management, together with outcome information. Results: A total of 28 patients with VGPAwere treated. The median age of the patients was 38 years with a range of 26 to 65 years. Sixteen of the 21 patients presented with abnormal bleeding, and 5 patients had an abnormal Papanicolaou (Pap) test result. Nineteen patients had International Federation of Gynecology and Obstetrics stage IB disease, and 5 patients had stage IIB disease. Two of 24 patients, where the lymph node status was known, had positive nodes. Twenty patients underwent different types of radical surgery with or without pelvic radiotherapy, and 8 patients received platinum-based chemotherapy and pelvic radiotherapy with no surgery. The follow-up ranged from 5 to 168 months with a median of 35 months. TwentyYone patients are alive with no evidence of recurrent disease, 5 patients have died because of the disease recurrence, and 2 patients were lost to follow-up. The overall and disease-free 5-year survival for these patients was 82% and 75%, respectively. Conclusion: This study confirms the excellent prognosis of VGPA overall compared to the common forms of cervical cancer, but the prognosis is related to stage and pathology. A large multicenter prospective study is warranted to determine the most appropriate treatment for the disease. Until then, a meta-analysis on the subject would be of benefit.

    Original languageEnglish (US)
    Pages (from-to)900-905
    Number of pages6
    JournalInternational Journal of Gynecological Cancer
    Volume23
    Issue number5
    DOIs
    StatePublished - Jun 1 2013

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    Keywords

    • Adenocarcinoma
    • Cervix
    • Lymph node
    • Papillary
    • Villoglandular

    ASJC Scopus subject areas

    • Oncology
    • Obstetrics and Gynecology

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