Visualization of tumor-related blood vessels in human breast by photoacoustic imaging system with a hemispherical detector array

M. Toi, Y. Asao, Y. Matsumoto, H. Sekiguchi, A. Yoshikawa, M. Takada, M. Kataoka, T. Endo, N. Kawaguchi-Sakita, M. Kawashima, E. Fakhrejahani, S. Kanao, I. Yamaga, Y. Nakayama, M. Tokiwa, M. Torii, T. Yagi, T. Sakurai, K. Togashi, T. Shiina

    Research output: Contribution to journalArticle

    83 Scopus citations

    Abstract

    Noninvasive measurement of the distribution and oxygenation state of hemoglobin (Hb) inside the tissue is strongly required to analyze the tumor-associated vasculatures. We developed a photoacoustic imaging (PAI) system with a hemispherical-shaped detector array (HDA). Here, we show that PAI system with HDA revealed finer vasculature, more detailed blood-vessel branching structures, and more detailed morphological vessel characteristics compared with MRI by the use of breast shape deformation of MRI to PAI and their fused image. Morphologically abnormal peritumoral blood vessel features, including centripetal photoacoustic signals and disruption or narrowing of vessel signals, were observed and intratumoral signals were detected by PAI in breast cancer tissues as a result of the clinical study of 22 malignant cases. Interestingly, it was also possible to analyze anticancer treatment-driven changes in vascular morphological features and function, such as improvement of intratumoral blood perfusion and relevant changes in intravascular hemoglobin saturation of oxygen. This clinical study indicated that PAI appears to be a promising tool for noninvasive analysis of human blood vessels and may contribute to improve cancer diagnosis.

    Original languageEnglish (US)
    Article number41970
    JournalScientific reports
    Volume7
    DOIs
    StatePublished - Feb 7 2017

      Fingerprint

    ASJC Scopus subject areas

    • General

    Cite this

    Toi, M., Asao, Y., Matsumoto, Y., Sekiguchi, H., Yoshikawa, A., Takada, M., Kataoka, M., Endo, T., Kawaguchi-Sakita, N., Kawashima, M., Fakhrejahani, E., Kanao, S., Yamaga, I., Nakayama, Y., Tokiwa, M., Torii, M., Yagi, T., Sakurai, T., Togashi, K., & Shiina, T. (2017). Visualization of tumor-related blood vessels in human breast by photoacoustic imaging system with a hemispherical detector array. Scientific reports, 7, [41970]. https://doi.org/10.1038/srep41970