When a G protein-coupled receptor does not couple to a G protein

Yutong Sun, Deirdre McGarrigle, Xin Yun Huang

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Classically, G protein-coupled receptors (GPCRs) relay signals by directly activating heterotrimeric guanine nucleotide-binding proteins (G proteins). Increasing evidence indicates that GPCRs may also signal through G protein-independent pathways. JAK/STATs, Src-family tyrosine kinases, GRKs/β-arrestins, and PDZ domain-containing proteins have been suggested to directly relay signals from GPCRs independent of G proteins. In addition, our laboratory recently reported that the β2 adrenergic receptor (β2AR) could switch from G protein-coupled to G protein-independent ERK (extracellular signal-regulated kinase) activation in an agonist dosage-dependent manner. This finding provides a novel mechanism for G protein-independent GPCR signaling. This review focuses on recent progress in understanding the mechanisms by which G protein-independent GPCR signaling occurs.

Original languageEnglish (US)
Pages (from-to)849-854
Number of pages6
JournalMolecular BioSystems
Volume3
Issue number12
DOIs
StatePublished - Jan 1 2007

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G-Protein-Coupled Receptors
GTP-Binding Proteins
Arrestins
PDZ Domains
Guanine Nucleotides
src-Family Kinases
Extracellular Signal-Regulated MAP Kinases
Adrenergic Receptors
Carrier Proteins
Proteins

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology

Cite this

When a G protein-coupled receptor does not couple to a G protein. / Sun, Yutong; McGarrigle, Deirdre; Huang, Xin Yun.

In: Molecular BioSystems, Vol. 3, No. 12, 01.01.2007, p. 849-854.

Research output: Contribution to journalArticle

Sun, Yutong ; McGarrigle, Deirdre ; Huang, Xin Yun. / When a G protein-coupled receptor does not couple to a G protein. In: Molecular BioSystems. 2007 ; Vol. 3, No. 12. pp. 849-854.
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