TY - GEN
T1 - White matter integrity in traumatic brain injury
T2 - 12th IEEE International Symposium on Biomedical Imaging, ISBI 2015
AU - Dennis, Emily L.
AU - Jin, Yan
AU - Kernan, Claudia
AU - Babikian, Talin
AU - Mink, Richard
AU - Babbitt, Christopher
AU - Johnson, Jeffrey
AU - Giza, Christopher C.
AU - Asarnow, Robert F.
AU - Thompson, Paul M.
N1 - Publisher Copyright:
© 2015 IEEE.
PY - 2015/7/21
Y1 - 2015/7/21
N2 - Traumatic brain injury (TBI) is the leading cause of death and disability in children. Diffusion weighted imaging (DWI) methods have been shown to be especially sensitive to white matter abnormalities in TBI. We used our newly developed autoMATE algorithm (automated multi-atlas tract extraction) to map altered WM integrity in TBI. Even so, tractography methods include a free parameter that limits the maximum permissible turning angles for extracted fibers, with little investigation of how this may affect statistical group comparisons. Here, we examined WM integrity calculated over a range of fiber turning angles to determine to what extent this parameter affects our ability to detect group differences. Fiber turning angle threshold has a subtle, but sometimes significant, effect on the differences we were able to detect between TBI and healthy children.
AB - Traumatic brain injury (TBI) is the leading cause of death and disability in children. Diffusion weighted imaging (DWI) methods have been shown to be especially sensitive to white matter abnormalities in TBI. We used our newly developed autoMATE algorithm (automated multi-atlas tract extraction) to map altered WM integrity in TBI. Even so, tractography methods include a free parameter that limits the maximum permissible turning angles for extracted fibers, with little investigation of how this may affect statistical group comparisons. Here, we examined WM integrity calculated over a range of fiber turning angles to determine to what extent this parameter affects our ability to detect group differences. Fiber turning angle threshold has a subtle, but sometimes significant, effect on the differences we were able to detect between TBI and healthy children.
KW - High angular resolution diffusion imaging (HARDI)
KW - fiber turning angle
KW - tractography
KW - traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=84938508513&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84938508513&partnerID=8YFLogxK
U2 - 10.1109/ISBI.2015.7164023
DO - 10.1109/ISBI.2015.7164023
M3 - Conference contribution
C2 - 26413206
AN - SCOPUS:84938508513
T3 - Proceedings - International Symposium on Biomedical Imaging
SP - 930
EP - 933
BT - 2015 IEEE 12th International Symposium on Biomedical Imaging, ISBI 2015
PB - IEEE Computer Society
Y2 - 16 April 2015 through 19 April 2015
ER -