Whole-pulmonary low-dose radiation therapy in agnogenic myeloid metaplasia with diffuse lung involvement

Patrcia Weinschenker, Jos M. Kutner, Joo V. Salvajoli, Rodrigo M. Hanriot, Andressa F. Ribeiro, Vera L. Capelozzi, Auro Del Giglio

    Research output: Contribution to journalArticle

    25 Scopus citations

    Abstract

    Agnogenic myeloid metaplasia is a hematologic disorder accompanied by extramedullary hematopoiesis (EMH) affecting various organs. Lung involvement however is rare. We present the case of a 76-year-old woman with myelofibrosis, recurrent pleural effusions, pulmonary hypertension, and serious right cardiac failure. An open lung biopsy confirmed pulmonary EMH. She underwent low-dose (200 cGy) whole-lung radiotherapy in 4 fractions of 50 cGy each. Her clinical and hemodynamic parameters improved. We conclude that low-dose whole-lung radiation may be efficacious for the palliative treatment of pulmonary EMH.

    Original languageEnglish (US)
    Pages (from-to)277-280
    Number of pages4
    JournalAmerican journal of hematology
    Volume69
    Issue number4
    DOIs
    StatePublished - Apr 9 2002

    Keywords

    • Agnogenic myeloid metaplasia
    • Extramedulary hematopoiesis
    • Low-dose whole-lung radiation

    ASJC Scopus subject areas

    • Hematology

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  • Cite this

    Weinschenker, P., Kutner, J. M., Salvajoli, J. V., Hanriot, R. M., Ribeiro, A. F., Capelozzi, V. L., & Giglio, A. D. (2002). Whole-pulmonary low-dose radiation therapy in agnogenic myeloid metaplasia with diffuse lung involvement. American journal of hematology, 69(4), 277-280. https://doi.org/10.1002/ajh.10075