TY - JOUR
T1 - Wilms Tumor Genetics
T2 - A New, UnX-pected Twist to the Story
AU - Huff, Vicki
PY - 2007/2/13
Y1 - 2007/2/13
N2 - The study of the genetics of Wilms tumor has led to several highly unexpected and precedent-establishing discoveries. Ironically, however, the identification of "WT genes" has been painfully slow, and gene mutations have been identified in only ∼25% of tumors. The discovery of an X chromosome gene, WTX, that is mutated somatically in ∼30% of Wilms tumors is notable both for helping to explain the genetic etiology of a substantial proportion of tumors and also for underscoring the role that X chromosome genes can play in cancer genetics.
AB - The study of the genetics of Wilms tumor has led to several highly unexpected and precedent-establishing discoveries. Ironically, however, the identification of "WT genes" has been painfully slow, and gene mutations have been identified in only ∼25% of tumors. The discovery of an X chromosome gene, WTX, that is mutated somatically in ∼30% of Wilms tumors is notable both for helping to explain the genetic etiology of a substantial proportion of tumors and also for underscoring the role that X chromosome genes can play in cancer genetics.
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U2 - 10.1016/j.ccr.2007.01.011
DO - 10.1016/j.ccr.2007.01.011
M3 - Short survey
C2 - 17292822
AN - SCOPUS:33846840952
SN - 1535-6108
VL - 11
SP - 105
EP - 107
JO - Cancer cell
JF - Cancer cell
IS - 2
ER -