TY - JOUR
T1 - Wilms' tumours
T2 - About tumour suppressor genes, an oncogene and a chameleon gene
AU - Huff, Vicki
N1 - Funding Information:
The author would like to thank C. Ruteshouser for her assistance. The author’s work is supported by US NIH grants CA34936 and DK069599, NCI CCSG grant CA16672 and CPRIT grants RP100329 and RP110234.
PY - 2011/2
Y1 - 2011/2
N2 - Genes identified as being mutated in Wilms' tumour include TP53, a classic tumour suppressor gene (TSG); CTNNB1 (encoding β 2-catenin), a classic oncogene; WTX, which accumulating data indicate is a TSG; and WT1, which is inactivated in some Wilms' tumours, similar to a TSG. However, WT1 does not always conform to the TSG label, and some data indicate that WT1 enhances cell survival and proliferation, like an oncogene. Is WT1 a chameleon, functioning as either a TSG or an oncogene, depending on cellular context? Are these labels even appropriate for describing and understanding the function of WT1?.
AB - Genes identified as being mutated in Wilms' tumour include TP53, a classic tumour suppressor gene (TSG); CTNNB1 (encoding β 2-catenin), a classic oncogene; WTX, which accumulating data indicate is a TSG; and WT1, which is inactivated in some Wilms' tumours, similar to a TSG. However, WT1 does not always conform to the TSG label, and some data indicate that WT1 enhances cell survival and proliferation, like an oncogene. Is WT1 a chameleon, functioning as either a TSG or an oncogene, depending on cellular context? Are these labels even appropriate for describing and understanding the function of WT1?.
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U2 - 10.1038/nrc3002
DO - 10.1038/nrc3002
M3 - Review article
C2 - 21248786
AN - SCOPUS:79151472081
SN - 1474-175X
VL - 11
SP - 111
EP - 121
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 2
ER -