Wisely chosen paths - regulation of rRNA synthesis: Delivered on 30 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

All cells, from prokaryotes to vertebrates, synthesize enormous amounts of rRNA to produce 1-2 million ribosomes per cell cycle, which are required to maintain the protein synthesis capacity of the daughter cells. In recent years, considerable progress has been made in the elucidation of the basic principles of transcriptional regulation and the pathways that adapt cellular rRNA synthesis to metabolic activity, a process that is essential for understanding the link between nucleolar activity, cell growth, proliferation, and apoptosis. I will survey our present knowledge of the highly coordinated networks that regulate transcription by RNA polymerase I, coordinating rRNA gene transcription and ribosome production with environmental cues. Moreover, I will discuss the epigenetic mechanisms that control the chromatin structure and transcriptional activity of rRNA genes, in particular the role of noncoding RNA in DNA methylation and transcriptional silencing.

Original languageEnglish (US)
Pages (from-to)4626-4639
Number of pages14
JournalFEBS Journal
Volume277
Issue number22
DOIs
StatePublished - Nov 1 2010

Fingerprint

Transcription
Ribosomes
rRNA Genes
Sweden
Genes
RNA Polymerase I
Untranslated RNA
Cell growth
DNA Methylation
Epigenomics
Chromatin
Cues
Vertebrates
Cell Cycle
Cells
Cell Proliferation
Apoptosis
Growth
Proteins
Surveys and Questionnaires

Keywords

  • Chromatin
  • Epigenetics
  • Noncoding RNA
  • RRNA genes
  • Signaling
  • Transcription

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Wisely chosen paths - regulation of rRNA synthesis : Delivered on 30 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden. / Grummt, Ingrid.

In: FEBS Journal, Vol. 277, No. 22, 01.11.2010, p. 4626-4639.

Research output: Contribution to journalArticle

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