Wiskott-Aldrich Syndrome causing mutation, Pro373Ser restricts conformational changes essential for WASP activity in T-cells

Keyphrases

• Protein Activity 100%
• T Cells 100%
• Conformational Change 100%
• Wiskott-Aldrich Syndrome 100%
• Wiskott-Aldrich Syndrome Protein 100%
• Proline-rich Region 22%
• T Cell Activation 11%
• Interacting Proteins 11%
• Chemotaxis 11%
• Binding Protein 5%
• Phosphorylation 5%
• Point mutation 5%
• Protein Complex 5%
• Tyrosine Phosphorylation 5%
• Protein Function 5%
• Jurkat T Cells 5%
• Rescue Experiments 5%
• Protein Binding 5%
• Protein Localization 5%
• Yeast Strains 5%
• Two-point 5%
• IL-2 Expression 5%
• Molecular Defects 5%
• Protein Chaperone 5%
• Protein Knockdown 5%
• Protein Homology 5%
• Nck1 5%
• Las17 5%
• Toca-1 5%

Immunology and Microbiology

• T Cell 100%
• Wiskott-Aldrich Syndrome 100%
• Proline 18%
• T Cell Activation 9%
• Protein Binding 9%
• Chemotaxis 9%
• Sequence Homology 4%
• Protein Phosphorylation 4%
• Interleukin 2 4%
• Point Mutation 4%
• Protein Function 4%
• Conformation 4%
• Protein Complex 4%
• Chaperone Protein 4%
• phosphorylation 4%