You can win by losing: p53 Mutations in rhabdomyosarcomas

Research output: Contribution to journalComment/debatepeer-review

2 Scopus citations

Abstract

Rhabdomyosarcomas are soft tissue sarcomas of mesenchymal origin. Unlike rhabdomyosarcomas observed in paediatric patients which typically respond well to chemotherapeutic treatment, adults generally present with pleomorphic rhabdomyosarcomas that are typically associated with poor prognosis. Therefore, understanding the molecular biology that gives rise to pleomorphic rhabdomyosarcomas is critical. In this issue of The Journal of Pathology, Doyle and colleagues have generated elegant tissue-specific Cre/loxP-dependent mouse models that mimic pleomorphic rhabdomyosarcoma development in humans. In this report, the authors employed KRasG12V-expressing mouse models that concomitantly either express mutant p53 (p53R172H) or have deleted the p53 gene. Mice that express mutant p53 have decreased survival with development of aggressive metastases as compared to mice that have simply lost wild-type p53. The data presented herein provide the first in vivo evidence that in rhabdomyosarcomas, expression of mutant p53 results in a more aggressive p53R172H-dependent gain-of-function phenotype.

Original languageEnglish (US)
Pages (from-to)124-128
Number of pages5
JournalJournal of Pathology
Volume222
Issue number2
DOIs
StatePublished - Oct 2010

Keywords

  • Cre
  • KRas
  • Metastasis
  • Mouse model
  • Rhabdomyosarcoma
  • loxP
  • p53

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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