YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis

Guoqiang Chang, Lei Shi, Youqiong Ye, Hailing Shi, Lixian Zeng, Shweta Tiwary, Jason T. Huse, Lei Huo, Li Ma, Yongjie Ma, Sicong Zhang, Jianwei Zhu, Victoria Xie, Peng Li, Leng Han, Chuan He, Suyun Huang

Research output: Contribution to journalArticlepeer-review

191 Scopus citations

Abstract

Chang et al. report that YTHDF3 overexpression associates with breast cancer brain metastasis and confers poor survival. Mechanistically, YTHDF3 enhances the expression of m6A-enriched transcripts that promote cancer cell-brain microenvironment interactions and brain metastasis.

Original languageEnglish (US)
Pages (from-to)857-871.e7
JournalCancer cell
Volume38
Issue number6
DOIs
StatePublished - Dec 14 2020

Keywords

  • YTHDF3
  • brain metastasis
  • epigenetic regulation
  • gene amplification
  • mA RNA methylation

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

MD Anderson CCSG core facilities

  • Small Animal Imaging Facility
  • Functional Proteomics Reverse Phase Protein Array Core
  • Bioinformatics Shared Resource

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