@article{23483e28bed243fcaa80bcc63ccb2234,
title = "YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis",
abstract = "Chang et al. report that YTHDF3 overexpression associates with breast cancer brain metastasis and confers poor survival. Mechanistically, YTHDF3 enhances the expression of m6A-enriched transcripts that promote cancer cell-brain microenvironment interactions and brain metastasis.",
keywords = "YTHDF3, brain metastasis, epigenetic regulation, gene amplification, mA RNA methylation",
author = "Guoqiang Chang and Lei Shi and Youqiong Ye and Hailing Shi and Lixian Zeng and Shweta Tiwary and Huse, {Jason T.} and Lei Huo and Li Ma and Yongjie Ma and Sicong Zhang and Jianwei Zhu and Victoria Xie and Peng Li and Leng Han and Chuan He and Suyun Huang",
note = "Funding Information: We thank Heidi Sankala and Lauren Hoffmann for language editing. We thank P. Steeg and B. Gril for proving the MDA-MB-231Br, JIMT-1 and JIMT-1-BR3 cells. We give thanks for the services of the VCU MCC Mouse Model and Microscopy Core Facilities, which are supported, in part, by NCI P30 CA016059 grant. This project was supported in part by US NIH grants RM1 HG008935 , and 1R01CA198090 , and by Paul M. Corman, MD Chair in Cancer Research endowment fund. C.H. is an investigator of the Howard Hughes Medical Institute . Funding Information: We thank Heidi Sankala and Lauren Hoffmann for language editing. We thank P. Steeg and B. Gril for proving the MDA-MB-231Br, JIMT-1 and JIMT-1-BR3 cells. We give thanks for the services of the VCU MCC Mouse Model and Microscopy Core Facilities, which are supported, in part, by NCI P30 CA016059 grant. This project was supported in part by US NIH grants RM1 HG008935, and 1R01CA198090, and by Paul M. Corman, MD Chair in Cancer Research endowment fund. C.H. is an investigator of the Howard Hughes Medical Institute. S.H. and C.H. conceived the project and designed the study. G.C. L.S. Y.Y. L.Z. H.S. S.T. L.M. J.Z. V.X. P.L. and S.Z. performed the experiments and/or analyzed the data. J.T.H. L. Huo, and L. Han provided critical reagents, resource, and/or clinical samples and scientific input. L. Han supervised data analyses of high-throughput sequencing data. G.C. L.S. C.H. and S.H. wrote and edited the manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = dec,
day = "14",
doi = "10.1016/j.ccell.2020.10.004",
language = "English (US)",
volume = "38",
pages = "857--871.e7",
journal = "Cancer cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "6",
}