TY - JOUR
T1 - Yttrium-90 Radioembolization in Intrahepatic Cholangiocarcinoma
T2 - A Multicenter Retrospective Analysis
AU - Buettner, Stefan
AU - Braat, Arthur J.A.T.
AU - Margonis, Georgios Antonios
AU - Brown, Daniel B.
AU - Taylor, Kevin B.
AU - Borgmann, Anthony J.
AU - Kappadath, S. Cheenu
AU - Mahvash, Armeen
AU - IJzermans, Jan N.M.
AU - Weiss, Matthew J.
AU - Lamarca, Angela
AU - Bell, Jon K.
AU - Valle, Juan W.
AU - Hagendoorn, Jeroen
AU - Koerkamp, Bas Groot
AU - Sze, Daniel Y.
AU - Lam, Marnix G.E.H.
N1 - Publisher Copyright:
© 2020 SIR
PY - 2020/7
Y1 - 2020/7
N2 - Purpose: To report outcomes of yttrium-90 (90Y) radioembolization in patients with unresectable intrahepatic cholangiocarcinoma (ICC). Materials and Methods: Retrospective review was performed of 115 patients at 6 tertiary care centers; 92 were treated with resin microspheres (80%), 22 were treated with glass microspheres (19%), and 1 was treated with both. Postintervention outcomes were compared between groups with χ2 tests. Survival after diagnosis and after treatment was assessed by Kaplan–Meier method. Results: Grade 3 laboratory toxicity was observed in 4 patients (4%); no difference in toxicity profile between resin and glass microspheres was observed (P = .350). Clinical toxicity per Society of Interventional Radiology criteria was noted in 29 patients (25%). Partial response per Response Evaluation Criteria In Solid Tumors 1.1 was noted in 25% of patients who underwent embolization with glass microspheres and 3% of patients who were treated with resin microspheres (P = .008). Median overall survival (OS) from first diagnosis was 29 months (95% confidence interval [CI], 21–37 mo) for all patients, and 1-, 3-, and 5-year OS rates were 85%, 31%, and 8%, respectively. Median OS after treatment was 11 months (95% CI, 8–13 mo), and 1- and 3-year OS rates were 44% and 4%, respectively. These estimates were not significantly different between resin and glass microspheres (P = .730 and P = .475, respectively). Five patients were able to undergo curative-intent resection after 90Y radioembolization (4%). Conclusions: This study provides observational data of treatment outcomes after 90Y radioembolization in patients with unresectable ICC.
AB - Purpose: To report outcomes of yttrium-90 (90Y) radioembolization in patients with unresectable intrahepatic cholangiocarcinoma (ICC). Materials and Methods: Retrospective review was performed of 115 patients at 6 tertiary care centers; 92 were treated with resin microspheres (80%), 22 were treated with glass microspheres (19%), and 1 was treated with both. Postintervention outcomes were compared between groups with χ2 tests. Survival after diagnosis and after treatment was assessed by Kaplan–Meier method. Results: Grade 3 laboratory toxicity was observed in 4 patients (4%); no difference in toxicity profile between resin and glass microspheres was observed (P = .350). Clinical toxicity per Society of Interventional Radiology criteria was noted in 29 patients (25%). Partial response per Response Evaluation Criteria In Solid Tumors 1.1 was noted in 25% of patients who underwent embolization with glass microspheres and 3% of patients who were treated with resin microspheres (P = .008). Median overall survival (OS) from first diagnosis was 29 months (95% confidence interval [CI], 21–37 mo) for all patients, and 1-, 3-, and 5-year OS rates were 85%, 31%, and 8%, respectively. Median OS after treatment was 11 months (95% CI, 8–13 mo), and 1- and 3-year OS rates were 44% and 4%, respectively. These estimates were not significantly different between resin and glass microspheres (P = .730 and P = .475, respectively). Five patients were able to undergo curative-intent resection after 90Y radioembolization (4%). Conclusions: This study provides observational data of treatment outcomes after 90Y radioembolization in patients with unresectable ICC.
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U2 - 10.1016/j.jvir.2020.02.008
DO - 10.1016/j.jvir.2020.02.008
M3 - Article
C2 - 32473757
AN - SCOPUS:85085290260
SN - 1051-0443
VL - 31
SP - 1035-1043.e2
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
IS - 7
ER -