Chad Huff

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Chad Huff

Professor

 https://orcid.org/0000-0002-1100-9364

    • 6767 Bertner Ave, Mitchell Basic Science Research Building

      77030 Houston

      United States

    Calculated based on number of publications stored in Pure and citations from Scopus
    20072024

    Research activity per year

    Search results

    • Article

      Accurate and robust prediction of genetic relationship from whole-genome sequences

      Li, H., Glusman, G., Huff, C., Caballero, J. & Roach, J. C., Feb 28 2014, In: PloS one. 9, 2, e85437.

      Research output: Contribution to journal › Article › peer-review

      14 Scopus citations

    • A comprehensive map of mobile element insertion polymorphisms in humans

      Stewart, C., Kural, D., Strömberg, M. P., Walker, J. A., Konkel, M. K., Stütz, A. M., Urban, A. E., Grubert, F., Lam, H. Y. K., Lee, W. P., Busby, M., Indap, A. R., Garrison, E., Huff, C., Xing, J., Snyder, M. P., Jorde, L. B., Batzer, M. A., Korbel, J. O. & Marth, G. T., Aug 2011, In: PLoS genetics. 7, 8, e1002236.

      Research output: Contribution to journal › Article › peer-review

      223 Scopus citations

    • Adaptive genetic changes related to haemoglobin concentration in native high-altitude Tibetans

      Simonson, T. S., Huff, C. D., Witherspoon, D. J., Prchal, J. T. & Jorde, L. B., Nov 1 2015, In: Experimental Physiology. 100, 11, p. 1263-1268 6 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      28 Scopus citations

    • A genetic mechanism for Tibetan high-altitude adaptation

      Lorenzo, F. R., Huff, C., Myllymäki, M., Olenchock, B., Swierczek, S., Tashi, T., Gordeuk, V., Wuren, T., Ge, R. L., McClain, D. A., Khan, T. M., Koul, P. A., Guchhait, P., Salama, M. E., Xing, J., Semenza, G. L., Liberzon, E., Wilson, A., Simonson, T. S., Jorde, L. B., & 3 othersKaelin, W. G., Koivunen, P. & Prchal, J. T., 2014, In: Nature Genetics. 46, 9, p. 951-956 6 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      303 Scopus citations

    • A genome-wide association study of prostate cancer in Latinos

      Du, Z., Hopp, H., Ingles, S. A., Huff, C., Sheng, X., Weaver, B., Stern, M., Hoffmann, T. J., John, E. M., Van Den Eeden, S. K., Strom, S., Leach, R. J., Thompson, I. M., Witte, J. S., Conti, D. V. & Haiman, C. A., Apr 1 2020, In: International journal of cancer. 146, 7, p. 1819-1826 8 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      23 Scopus citations

    • A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry

      Darst, B. F., Wan, P., Sheng, X., Bensen, J. T., Ingles, S. A., Rybicki, B. A., Nemesure, B., John, E. M., Fowke, J. H., Stevens, V. L., Berndt, S. I., Huff, C. D., Strom, S. S., Park, J. Y., Zheng, W., Ostrander, E. A., Walsh, P. C., Srivastava, S., Carpten, J., Sellers, T. A., & 52 othersYamoah, K., Murphy, A. B., Sanderson, M., Crawford, D. C., Gapstur, S. M., Bush, W. S., Aldrich, M. C., Cussenot, O., Yeager, M., Petrovics, G., Cullen, J., Neslund-Dudas, C., Kittles, R. A., Xu, J., Stern, M. C., Kote-Jarai, Z., Govindasami, K., Chokkalingam, A. P., Multigner, L., Parent, M. E., Menegaux, F., Cancel-Tassin, G., Kibel, A. S., Klein, E. A., Goodman, P. J., Drake, B. F., Hu, J. J., Clark, P. E., Blanchet, P., Casey, G., Hennis, A. J. M., Lubwama, A., Thompson, I. M., Leach, R., Gundell, S. M., Pooler, L., Xia, L., Mohler, J. L., Fontham, E. T. H., Smith, G. J., Taylor, J. A., Eeles, R. A., Brureau, L., Chanock, S. J., Watya, S., Stanford, J. L., Mandal, D., Isaacs, W. B., Cooney, K., Blot, W. J., Conti, D. V. & Haiman, C. A., Sep 2020, In: European urology. 78, 3, p. 316-320 5 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      29 Scopus citations

    • ALPK1 missense pathogenic variant in five families leads to ROSAH syndrome, an ocular multisystem autosomal dominant disorder

      Williams, L. B., Javed, A., Sabri, A., Morgan, D. J., Huff, C. D., Grigg, J. R., Heng, X. T., Khng, A. J., Hollink, I. H. I. M., Morrison, M. A., Owen, L. A., Anderson, K., Kinard, K., Greenlees, R., Novacic, D., Nida Sen, H., Zein, W. M., Rodgers, G. M., Vitale, A. T., Haider, N. B., & 21 othersHillmer, A. M., Ng, P. C., Shankaracharya, Cheng, A., Zheng, L., Gillies, M. C., van Slegtenhorst, M., van Hagen, P. M., Missotten, T. O. A. R., Farley, G. L., Polo, M., Malatack, J., Curtin, J., Martin, F., Arbuckle, S., Alexander, S. I., Chircop, M., Davila, S., Digre, K. B., Jamieson, R. V. & DeAngelis, M. M., Sep 1 2019, In: Genetics in Medicine. 21, 9, p. 2103-2115 13 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      28 Scopus citations

    • Alternating hemiplegia of childhood: Retrospective genetic study and genotype-phenotype correlations in 187 subjects from the US AHCF registry

      Viollet, L., Glusman, G., Murphy, K. J., Newcomb, T. M., Reyna, S. P., Sweney, M., Nelson, B., Andermann, F., Andermann, E., Acsadi, G., Barbano, R. L., Brown, C., Brunkow, M. E., Chugani, H. T., Cheyette, S. R., Collins, A., DeBrosse, S. D., Galas, D., Friedman, J., Hood, L., & 21 othersHuff, C., Jorde, L. B., King, M. D., LaSalle, B., Leventer, R. J., Lewelt, A. J., Massart, M. B., Mérida, M. R., Ptáček, L. J., Roach, J. C., Rust, R. S., Renault, F., Sanger, T. D., De Menezes, M. A. S., Tennyson, R., Uldall, P., Zhang, Y., Zupanc, M., Xin, W., Silver, K. & Swoboda, K. J., May 21 2015, In: PloS one. 10, 5, e0127045.

      Research output: Contribution to journal › Article › peer-review

      62 Scopus citations

    • Analysis of genetic inheritance in a family quartet by whole-genome sequencing

      Roach, J. C., Glusman, G., Smit, A. F. A., Huff, C. D., Hubley, R., Shannon, P. T., Rowen, L., Pant, K. P., Goodman, N., Bamshad, M., Shendure, J., Drmanac, R., Jorde, L. B., Hood, L. & Galas, D. J., Apr 30 2010, In: Science. 328, 5978, p. 636-639 4 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      827 Scopus citations

    • Ancestral alleles and population origins: Inferences depend on mutation rate

      Rogers, A. R., Wooding, S., Huff, C. D., Batzer, M. A. & Jorde, L. B., Apr 2007, In: Molecular biology and evolution. 24, 4, p. 990-997 8 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      9 Scopus citations

    • Ancestry of the iban is predominantly Southeast Asian: Genetic evidence from autosomal, Mitochondrial, and Y Chromosomes

      Simonson, T. S., Xing, J., Barrett, R., Jerah, E., Loa, P., Zhang, Y., Watkins, W. S., Witherspoon, D. J., Huff, C. D., Woodward, S., Mowry, B. & Jorde, L. B., 2011, In: PloS one. 6, 1, e16338.

      Research output: Contribution to journal › Article › peer-review

      13 Scopus citations

    • A Nonsynonymous Variant in the GOLM1 Gene in Cutaneous Malignant Melanoma

      Teerlink, C. C., Huff, C., Stevens, J., Yu, Y., Holmen, S. L., Silvis, M. R., Trombetti, K., Zhao, H., Grossman, D., Farnham, J. M., Wen, J., Facelli, J. C., Thomas, A., Babst, M., Florell, S. R., Meyer, L., Zone, J. J., Leachman, S. & Cannon-Albright, L. A., Dec 1 2018, In: Journal of the National Cancer Institute. 110, 12, p. 1380-1385 6 p.

      Research output: Contribution to journal › Article › peer-review

      27 Scopus citations

    • A probabilistic disease-gene finder for personal genomes

      Yandell, M., Huff, C., Hu, H., Singleton, M., Moore, B., Xing, J., Jorde, L. B. & Reese, M. G., Sep 2011, In: Genome research. 21, 9, p. 1529-1542 14 p.

      Research output: Contribution to journal › Article › peer-review

      157 Scopus citations

    • A Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry

      Darst, B. F., Hughley, R., Pfennig, A., Hazra, U., Fan, C., Wan, P., Sheng, X., Xia, L., Andrews, C., Chen, F., Berndt, S. I., Kote-Jarai, Z., Govindasami, K., Bensen, J. T., Ingles, S. A., Rybicki, B. A., Nemesure, B., John, E. M., Fowke, J. H., Huff, C. D., & 81 othersStrom, S. S., Isaacs, W. B., Park, J. Y., Zheng, W., Ostrander, E. A., Walsh, P. C., Carpten, J., Sellers, T. A., Yamoah, K., Murphy, A. B., Sanderson, M., Crawford, D. C., Gapstur, S. M., Bush, W. S., Aldrich, M. C., Cussenot, O., Petrovics, G., Cullen, J., Neslund-Dudas, C., Kittles, R. A., Xu, J., Stern, M. C., Chokkalingam, A. P., Multigner, L., Parent, M. E., Menegaux, F., Cancel-Tassin, G., Kibel, A. S., Klein, E. A., Goodman, P. J., Stanford, J. L., Drake, B. F., Hu, J. J., Clark, P. E., Blanchet, P., Casey, G., Hennis, A. J. M., Lubwama, A., Thompson, I. M., Leach, R. J., Gundell, S. M., Pooler, L., Mohler, J. L., Fontham, E. T. H., Smith, G. J., Taylor, J. A., Brureau, L., Blot, W. J., Biritwum, R., Tay, E., Truelove, A., Niwa, S., Tettey, Y., Varma, R., McKean-Cowdin, R., Torres, M., Jalloh, M., Magueye Gueye, S., Niang, L., Ogunbiyi, O., Oladimeji Idowu, M., Popoola, O., Adebiyi, A. O., Aisuodionoe-Shadrach, O. I., Nwegbu, M., Adusei, B., Mante, S., Darkwa-Abrahams, A., Yeboah, E. D., Mensah, J. E., Anthony Adjei, A., Diop, H., Cook, M. B., Chanock, S. J., Watya, S., Eeles, R. A., Chiang, C. W. K., Lachance, J., Rebbeck, T. R., Conti, D. V. & Haiman, C. A., May 2022, In: European urology. 81, 5, p. 458-462 5 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      16 Scopus citations

    • Assessing the performance of in silico methods for predicting the pathogenicity of variants in the gene CHEK2, among Hispanic females with breast cancer

      Voskanian, A., Katsonis, P., Lichtarge, O., Pejaver, V., Radivojac, P., Mooney, S. D., Capriotti, E., Bromberg, Y., Wang, Y., Miller, M., Martelli, P. L., Savojardo, C., Babbi, G., Casadio, R., Cao, Y., Sun, Y., Shen, Y., Garg, A., Pal, D., Yu, Y., & 9 othersHuff, C. D., Tavtigian, S. V., Young, E., Neuhausen, S. L., Ziv, E., Pal, L. R., Andreoletti, G., Brenner, S. E. & Kann, M. G., Sep 1 2019, In: Human mutation. 40, 9, p. 1612-1622 11 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      6 Scopus citations

    • Association between Birth Defects and Cancer Risk among Children and Adolescents in a Population-Based Assessment of 10 Million Live Births

      Lupo, P. J., Schraw, J. M., Desrosiers, T. A., Nembhard, W. N., Langlois, P. H., Canfield, M. A., Copeland, G., Meyer, R. E., Brown, A. L., Chambers, T. M., Sok, P., Danysh, H. E., Carozza, S. E., Sisoudiya, S. D., Hilsenbeck, S. G., Janitz, A. E., Oster, M. E., Scheuerle, A. E., Schiffman, J. D., Luo, C., & 6 othersMian, A., Mueller, B. A., Huff, C. D., Rasmussen, S. A., Scheurer, M. E. & Plon, S. E., Aug 2019, In: JAMA Oncology. 5, 8, p. 1150-1158 9 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      85 Scopus citations

    • A unified test of linkage analysis and rare-variant association for analysis of pedigree sequence data

      Hu, H., Roach, J. C., Coon, H., Guthery, S. L., Voelkerding, K. V., Margraf, R. L., Durtschi, J. D., Tavtigian, S. V., Shankaracharya, Wu, W., Scheet, P., Wang, S., Xing, J., Glusman, G., Hubley, R., Li, H., Garg, V., Moore, B., Hood, L., Galas, D. J., & 5 othersSrivastava, D., Reese, M. G., Jorde, L. B., Yandell, M. & Huff, C. D., Jul 2014, In: Nature biotechnology. 32, 7, p. 663-669 7 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      76 Scopus citations

    • A west African ancestry-associated SNP on 8q24 predicts a positive biopsy in African American men with suspected prostate cancer following PSA screening

      Gu, J., Chery, L., González, G. M. N., Huff, C., Strom, S., Jones, J. A., Griffith, D. P., Canfield, S. E., Wang, X., Huang, X., Roberson, P., Meng, Q. H., Troncoso, P., Ittmann, M., Covinsky, M., Scheurer, M., Irizarry Ramirez, M. & Pettaway, C. A., May 15 2024, In: Prostate. 84, 7, p. 694-705 12 p.

      Research output: Contribution to journal › Article › peer-review

    • A whole-exome case-control association study to characterize the contribution of rare coding variation to pancreatic cancer risk

      Yu, Y., Chang, K., Chen, J. S., Bohlender, R. J., Fowler, J., Zhang, D., Huang, M., Chang, P., Li, Y., Wong, J., Wang, H., Gu, J., Wu, X., Schildkraut, J., Cannon-Albright, L., Ye, Y., Zhao, H., Hildebrandt, M. A. T., Permuth, J. B., Li, D., & 2 othersScheet, P. & Huff, C. D., Jan 13 2022, In: Human Genetics and Genomics Advances. 3, 1, 100078.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods

      The Critical Assessment of Genome Interpretation Consortium, Dec 2024, In: Genome biology. 25, 1, 53.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

      The Biobank Japan Project, Dec 2023, In: Nature Genetics. 55, 12, p. 2065-2074 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      5 Scopus citations

    • Clonal hematopoiesis and risk of prostate cancer in large samples of European ancestry men

      Wang, A., Xu, Y., Yu, Y., Nead, K. T., Kim, T. B., Xu, K., Dadaev, T., Saunders, E., Sheng, X., Wan, P., Pooler, L., Xia, L. Y., Chanock, S., Berndt, S. I., Gapstur, S. M., Stevens, V., Albanes, D., Weinstein, S. J., Gnanapragasam, V., Giles, G. G., & 19 othersNguyen-Dumont, T., Milne, R. L., Pomerantz, M. M., Schmidt, J. A., Stopsack, K. H., Mucci, L. A., Catalona, W. J., Hetrick, K. N., Doheny, K. F., MacInnis, R. J., Southey, M. C., Eeles, R. A., Wiklund, F., Kote-Jarai, Z., Smith, A. J., Conti, D. V., Huff, C., Haiman, C. A. & Darst, B. F., Feb 1 2023, In: Human molecular genetics. 32, 3, p. 489-495 7 p.

      Research output: Contribution to journal › Article › peer-review

      1 Scopus citations

    • Copy number variants are ovarian cancer risk alleles at known and novel risk loci

      Devries, A. A., Dennis, J., Tyrer, J. P., Peng, P. C., Coetzee, S. G., Reyes, A. L., Plummer, J. T., Davis, B. D., Chen, S. S., Dezem, F. S., Aben, K. K. H., Anton-Culver, H., Antonenkova, N. N., Beckmann, M. W., Beeghly-Fadiel, A., Berchuck, A., Bogdanova, N. V., Bogdanova-Markov, N., Brenton, J. D., Butzow, R., & 68 othersCampbell, I., Chang-Claude, J., Chenevix-Trench, G., Cook, L. S., Defazio, A., Doherty, J. A., Dork, T., Eccles, D. M., Eliassen, A. H., Fasching, P. A., Fortner, R. T., Giles, G. G., Goode, E. L., Goodman, M. T., Gronwald, J., Hakansson, N., Hildebrandt, M. A. T., Huff, C., Huntsman, D. G., Jensen, A., Kar, S., Karlan, B. Y., Khusnutdinova, E. K., Kiemeney, L. A., Kjaer, S. K., Kupryjanczyk, J., Labrie, M., Lambrechts, D., Le, N. D., Lubinski, J., May, T., Menon, U., Milne, R. L., Modugno, F., Monteiro, A. N., Moysich, K. B., Odunsi, K., Olsson, H., Pearce, C. L., Pejovic, T., Ramus, S. J., Riboli, E., Riggan, M. J., Romieu, I., Sandler, D. P., Schildkraut, J. M., Setiawan, V. W., Sieh, W., Song, H., Sutphen, R., Terry, K. L., Thompson, P. J., Titus, L., Tworoger, S. S., Van Nieuwenhuysen, E., Edwards, D. V., Webb, P. M., Wentzensen, N., Whittemore, A. S., Wolk, A., Wu, A. H., Ziogas, A., Freedman, M. L., Lawrenson, K., Pharoah, P. D. P., Easton, D. F., Gayther, S. A. & Jones, M. R., Nov 1 2022, In: Journal of the National Cancer Institute. 114, 11, p. 1533-1544 12 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      3 Scopus citations

    • Crohn's disease and genetic hitchhiking at IBD5

      Huff, C. D., Witherspoon, D. J., Zhang, Y., Gatenbee, C., Denson, L. A., Kugathasan, S., Hakonarson, H., Whiting, A., Davis, C. T., Wu, W., Xing, J., Watkins, W. S., Bamshad, M. J., Bradfield, J. P., Bulayeva, K., Simonson, T. S., Jorde, L. B. & Guthery, S. L., Jan 2012, In: Molecular biology and evolution. 29, 1, p. 101-111 11 p.

      Research output: Contribution to journal › Article › peer-review

      42 Scopus citations

    • De novo mutations in ATP1A3 cause alternating hemiplegia of childhood

      Heinzen, E. L., Swoboda, K. J., Hitomi, Y., Gurrieri, F., De Vries, B., Tiziano, F. D., Fontaine, B., Walley, N. M., Heavin, S., Panagiotakaki, E., Fiori, S., Abiusi, E., Di Pietro, L., Sweney, M. T., Newcomb, T. M., Viollet, L., Huff, C., Jorde, L. B., Reyna, S. P., Murphy, K. J., & 58 othersShianna, K. V., Gumbs, C. E., Little, L., Silver, K., Ptáček, L. J., Haan, J., Ferrari, M. D., Bye, A. M., Herkes, G. K., Whitelaw, C. M., Webb, D., Lynch, B. J., Uldall, P., King, M. D., Scheffer, I. E., Neri, G., Arzimanoglou, A., Van Den Maagdenberg, A. M. J. M., Sisodiya, S. M., Mikati, M. A., Goldstein, D. B., Koelewijn, S., Kamphorst, J., Geilenkirchen, M., Pelzer, N., Ferrari, M., Van Den Maagdenberg, A., Zucca, C., Franchini, F., Vavassori, R., Giannotta, M., Gobbi, G., Granata, T., Nardocci, N., De Grandis, E., Veneselli, E., Stagnaro, M., Vigevano, F., Oechsler, C., Nicole, S., Ninan, M., Neville, B., Ebinger, F., Fons, C., Campistol, J., Kemlink, D., Nevsimalova, S., Laan, L., Peeters-Scholte, C., Casaer, P., Casari, G., Sange, G., Spiel, G., Boneschi, F. M., Bassi, M. T., Schyns, T., Crawley, F. & Poncelin, D., Sep 2012, In: Nature Genetics. 44, 9, p. 1030-1034 5 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      328 Scopus citations

    • Detecting positive selection from genome scans of linkage disequilibrium

      Huff, C. D., Harpending, H. C. & Rogers, A. R., Jan 5 2010, In: BMC genomics. 11, 1, 0.

      Research output: Contribution to journal › Article › peer-review

      16 Scopus citations

    • Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African ancestry anthropometry genetics consortium

      The Bone Mineral Density in Childhood Study (BMDCS) Group, Apr 2017, In: PLoS genetics. 13, 4, e1006719.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      76 Scopus citations

    • Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry

      Graff, M., Justice, A. E., Young, K. L., Marouli, E., Zhang, X., Fine, R. S., Lim, E., Buchanan, V., Rand, K., Feitosa, M. F., Wojczynski, M. K., Yanek, L. R., Shao, Y., Rohde, R., Adeyemo, A. A., Aldrich, M. C., Allison, M. A., Ambrosone, C. B., Ambs, S., Amos, C., & 205 othersArnett, D. K., Atwood, L., Bandera, E. V., Bartz, T., Becker, D. M., Berndt, S. I., Bernstein, L., Bielak, L. F., Blot, W. J., Bottinger, E. P., Bowden, D. W., Bradfield, J. P., Brody, J. A., Broeckel, U., Burke, G., Cade, B. E., Cai, Q., Caporaso, N., Carlson, C., Carpten, J., Casey, G., Chanock, S. J., Chen, G., Chen, M., Chen, Y. D. I., Chen, W. M., Chesi, A., Chiang, C. W. K., Chu, L., Coetzee, G. A., Conti, D. V., Cooper, R. S., Cushman, M., Demerath, E., Deming, S. L., Dimitrov, L., Ding, J., Diver, W. R., Duan, Q., Evans, M. K., Falusi, A. G., Faul, J. D., Fornage, M., Fox, C., Freedman, B. I., Garcia, M., Gillanders, E. M., Goodman, P., Gottesman, O., Grant, S. F. A., Guo, X., Hakonarson, H., Haritunians, T., Harris, T. B., Harris, C. C., Henderson, B. E., Hennis, A., Hernandez, D. G., Hirschhorn, J. N., McNeill, L. H., Howard, T. D., Howard, B., Hsing, A. W., Hsu, Y. H. H., Hu, J. J., Huff, C. D., Huo, D., Ingles, S. A., Irvin, M. R., John, E. M., Johnson, K. C., Jordan, J. M., Kabagambe, E. K., Kang, S. J., Kardia, S. L., Keating, B. J., Kittles, R. A., Klein, E. A., Kolb, S., Kolonel, L. N., Kooperberg, C., Kuller, L., Kutlar, A., Lange, L., Langefeld, C. D., Le Marchand, L., Leonard, H., Lettre, G., Levin, A. M., Li, Y., Li, J., Liu, Y., Liu, Y., Liu, S., Lohman, K., Lotay, V., Lu, Y., Maixner, W., Manson, J. A. E., McKnight, B., Meng, Y., Monda, K. L., Monroe, K., Moore, J. H., Mosley, T. H., Mudgal, P., Murphy, A. B., Nadukuru, R., Nalls, M. A., Nathanson, K. L., Nayak, U., N'Diaye, A., Nemesure, B., Neslund-Dudas, C., Neuhouser, M. L., Nyante, S., Ochs-Balcom, H., Ogundiran, T. O., Ogunniyi, A., Ojengbede, O., Okut, H., Olopade, O. I., Olshan, A., Padhukasahasram, B., Palmer, J., Palmer, C. D., Palmer, N. D., Papanicolaou, G., Patel, S. R., Pettaway, C. A., Peyser, P. A., Press, M. F., Rao, D. C., Rasmussen-Torvik, L. J., Redline, S., Reiner, A. P., Rhie, S. K., Rodriguez-Gil, J. L., Rotimi, C. N., Rotter, J. I., Ruiz-Narvaez, E. A., Rybicki, B. A., Salako, B., Sale, M. M., Sanderson, M., Schadt, E., Schreiner, P. J., Schurmann, C., Schwartz, A. G., Shriner, D. A., Signorello, L. B., Singleton, A. B., Siscovick, D. S., Smith, J. A., Smith, S., Speliotes, E., Spitz, M., Stanford, J. L., Stevens, V. L., Stram, A., Strom, S. S., Sucheston, L., Sun, Y. V., Tajuddin, S. M., Taylor, H., Taylor, K., Tayo, B. O., Thun, M. J., Tucker, M. A., Vaidya, D., Van Den Berg, D. J., Vedantam, S., Vitolins, M., Wang, Z., Ware, E. B., Wassertheil-Smoller, S., Weir, D. R., Wiencke, J. K., Williams, S. M., Williams, L. K., Wilson, J. G., Witte, J. S., Wrensch, M., Wu, X., Yao, J., Zakai, N., Zanetti, K., Zemel, B. S., Zhao, W., Zhao, J. H., Zheng, W., Zhi, D., Zhou, J., Zhu, X., Ziegler, R. G., Zmuda, J., Zonderman, A. B., Psaty, B. M., Borecki, I. B., Cupples, L. A., Liu, C. T., Haiman, C. A., Loos, R., Ng, M. C. Y. & North, K. E., Apr 1 2021, In: American journal of human genetics. 108, 4, p. 564-582 19 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      15 Scopus citations

    • DNA Polymerase Epsilon Deficiency Causes IMAGe Syndrome with Variable Immunodeficiency

      SGP Consortium, Dec 6 2018, In: American journal of human genetics. 103, 6, p. 1038-1044 7 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      65 Scopus citations

    • DNA Sequencing of Small Bowel Adenocarcinomas Identifies Targetable Recurrent Mutations in the ERBB2 Signaling Pathway

      Adam, L., San Lucas, F. A., Fowler, R., Yu, Y., Wu, W., Liu, Y., Wang, H., Menter, D., Tetzlaff, M. T., Ensor, J., Manyam, G., Arold, S. T., Huff, C., Kopetz, S., Scheet, P. & Overman, M. J., Jan 15 2019, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 25, 2, p. 641-651 11 p.

      Research output: Contribution to journal › Article › peer-review

      21 Scopus citations

    • Early history of Neanderthals and Denisovans

      Rogers, A. R., Bohlender, R. J. & Huff, C. D., Sep 12 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 37, p. 9859-9863 5 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      55 Scopus citations

    • Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry

      NC-LA PCaP Investigators & Canary PASS Investigators, Jul 6 2023, In: American journal of human genetics. 110, 7, p. 1200-1206 7 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      2 Scopus citations

    • Evidence of Novel Susceptibility Variants for Prostate Cancer and a Multiancestry Polygenic Risk Score Associated with Aggressive Disease in Men of African Ancestry

      Chen, F., Madduri, R. K., Rodriguez, A. A., Darst, B. F., Chou, A., Sheng, X., Wang, A., Shen, J., Saunders, E. J., Rhie, S. K., Bensen, J. T., Ingles, S. A., Kittles, R. A., Strom, S. S., Rybicki, B. A., Nemesure, B., Isaacs, W. B., Stanford, J. L., Zheng, W., Sanderson, M., & 98 othersJohn, E. M., Park, J. Y., Xu, J., Wang, Y., Berndt, S. I., Huff, C. D., Yeboah, E. D., Tettey, Y., Lachance, J., Tang, W., Rentsch, C. T., Cho, K., Mcmahon, B. H., Biritwum, R. B., Adjei, A. A., Tay, E., Truelove, A., Niwa, S., Sellers, T. A., Yamoah, K., Murphy, A. B., Crawford, D. C., Patel, A. V., Bush, W. S., Aldrich, M. C., Cussenot, O., Petrovics, G., Cullen, J., Neslund-Dudas, C. M., Stern, M. C., Kote-Jarai, Z., Govindasami, K., Cook, M. B., Chokkalingam, A. P., Hsing, A. W., Goodman, P. J., Hoffmann, T. J., Drake, B. F., Hu, J. J., Keaton, J. M., Hellwege, J. N., Clark, P. E., Jalloh, M., Gueye, S. M., Niang, L., Ogunbiyi, O., Idowu, M. O., Popoola, O., Adebiyi, A. O., Aisuodionoe-Shadrach, O. I., Ajibola, H. O., Jamda, M. A., Oluwole, O. P., Nwegbu, M., Adusei, B., Mante, S., Darkwa-Abrahams, A., Mensah, J. E., Diop, H., Van Den Eeden, S. K., Blanchet, P., Fowke, J. H., Casey, G., Hennis, A. J., Lubwama, A., Thompson, I. M., Leach, R., Easton, D. F., Preuss, M. H., Loos, R. J., Gundell, S. M., Wan, P., Mohler, J. L., Fontham, E. T., Smith, G. J., Taylor, J. A., Srivastava, S., Eeles, R. A., Carpten, J. D., Kibel, A. S., Multigner, L., Parent, M. É., Menegaux, F., Cancel-Tassin, G., Klein, E. A., Andrews, C., Rebbeck, T. R., Brureau, L., Ambs, S., Edwards, T. L., Watya, S., Chanock, S. J., Witte, J. S., Blot, W. J., Michael Gaziano, J., Justice, A. C., Conti, D. V. & Haiman, C. A., Jul 2023, In: European urology. 84, 1, p. 13-21 9 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      10 Scopus citations

    • Evolutionary history of Tibetans inferred from whole-genome sequencing

      Hu, H., Petousi, N., Glusman, G., Yu, Y., Bohlender, R. J., Tashi, T., Downie, J. M., Roach, J. C., Cole, A. M., Lorenzo, F. R., Rogers, A. R., Brunkow, M. E., Cavalleri, G., Hood, L., Alpatty, S. M., Prchal, J. T., Jorde, L. B., Robbins, P. A., Simonson, T. S. & Huff, C. D., Apr 2017, In: PLoS genetics. 13, 4, e1006675.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      73 Scopus citations

    • Evolutionary selected Tibetan variants of HIF pathway and risk of lung cancer

      Lanikova, L., Scott Reading, N., Hu, H., Tashi, T., Burjanivova, T., Shestakova, A., Siwakoti, B., Thakur, B. K., Pun, C. B., Sapkota, A., Abdelaziz, S., Feng, B. J., Huff, C. D., Hashibe, M. & Prchal, J. T., 2017, In: Oncotarget. 8, 7, p. 11739-11747 9 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      14 Scopus citations

    • Exome sequencing identifies the cause of a mendelian disorder

      Ng, S. B., Buckingham, K. J., Lee, C., Bigham, A. W., Tabor, H. K., Dent, K. M., Huff, C. D., Shannon, P. T., Jabs, E. W., Nickerson, D. A., Shendure, J. & Bamshad, M. J., Jan 2010, In: Nature Genetics. 42, 1, p. 30-35 6 p.

      Research output: Contribution to journal › Article › peer-review

      1533 Scopus citations

    • Functional EPAS1/HIF2A missense variant is associated with hematocrit in Andean highlanders

      Lawrence, E. S., Gu, W., Bohlender, R. J., Anza-Ramirez, C., Cole, A. M., Yu, J. J., Hu, H., Heinrich, E. C., O’Brien, K. A., Vasquez, C. A., Cowan, Q. T., Bruck, P. T., Mercader, K., Alotaibi, M., Long, T., Hall, J. E., Moya, E. A., Bauk, M. A., Reeves, J. J., Kong, M. C., & 19 othersSalem, R. M., Vizcardo-Galindo, G., Macarlupu, J. L., Figueroa-Mujíca, R., Bermudez, D., Corante, N., Gaio, E., Fox, K. P., Salomaa, V., Havulinna, A. S., Murray, A. J., Malhotra, A., Powel, F. L., Jain, M., Komor, A. C., Cavalleri, G. L., Huff, C. D., Villafuerte, F. C. & Simonson, T. S., Feb 2024, In: Science Advances. 10, 6, eadj5661.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Functionally oriented analysis of cardiometabolic traits in a trans-ethnic sample

      Petty, L. E., Highland, H. M., Gamazon, E. R., Hu, H., Karhade, M., Chen, H. H., De Vries, P. S., Grove, M. L., Aguilar, D., Bell, G. I., Huff, C. D., Hanis, C. L., Doddapaneni, H., Munzy, D. M., Gibbs, R. A., Ma, J., Parra, E. J., Cruz, M., Valladares-Salgado, A., Arking, D. E., & 5 othersBarbeira, A., Im, H. K., Morrison, A. C., Boerwinkle, E. & Below, J. E., Apr 1 2019, In: Human molecular genetics. 28, 7, p. 1212-1224 13 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      10 Scopus citations

    • Gain-of-function EGLN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2α) polymorphism lowers hemoglobin concentration in Tibetan highlanders

      Tashi, T., Scott Reading, N., Wuren, T., Zhang, X., Moore, L. G., Hu, H., Tang, F., Shestakova, A., Lorenzo, F., Burjanivova, T., Koul, P., Guchhait, P., Wittwer, C. T., Julian, C. G., Shah, B., Huff, C. D., Gordeuk, V. R., Prchal, J. T. & Ge, R. L., Jun 1 2017, In: Journal of Molecular Medicine. 95, 6, p. 665-670 6 p.

      Research output: Contribution to journal › Article › peer-review

      49 Scopus citations

    • Genetic analysis of ancestry, admixture and selection in Bolivian and Totonac populations of the New World

      Watkins, W. S., Xing, J., Huff, C., Witherspoon, D. J., Zhang, Y., Perego, U. A., Woodward, S. R. & Jorde, L. B., May 20 2012, In: BMC genetics. 13, 39.

      Research output: Contribution to journal › Article › peer-review

      19 Scopus citations

    • Genetic diversity in India and the inference of Eurasian population expansion

      Xing, J., Watkins, W. S., Hu, Y., Huff, C. D., Sabo, A., Muzny, D. M., Bamshad, M. J., Gibbs, R. A., Jorde, L. B. & Yu, F., Nov 24 2010, In: Genome biology. 11, 11, R113.

      Research output: Contribution to journal › Article › peer-review

      58 Scopus citations

    • Genetic evidence for high-altitude adaptation in Tibet

      Simonson, T. S., Yang, Y., Huff, C. D., Yun, H., Qin, G., Witherspoon, D. J., Bai, Z., Lorenzo, F. R., Xing, J., Jorde, L. B., Prchal, J. T. & Ge, R. L., Jul 2 2010, In: Science. 329, 5987, p. 72-75 4 p.

      Research output: Contribution to journal › Article › peer-review

      876 Scopus citations

    • Genetic risk factors in two Utah pedigrees at high risk for suicide

      Coon, H., Darlington, T., Pimentel, R., Smith, K. R., Huff, C. D., Hu, H., Jerominski, L., Hansen, J., Klein, M., Callor, W. B., Byrd, J., Bakian, A., Crowell, S. E., McMahon, W. M., Rajamanickam, V., Camp, N. J., McGlade, E., Yurgelun-Todd, D., Grey, T. & Gray, D., Nov 19 2013, In: Translational psychiatry. 3, 3.

      Research output: Contribution to journal › Article › peer-review

      30 Scopus citations

    • Genome-wide association study of staphylococcus aureus carriage in a community-based sample of Mexican-Americans in Starr County, Texas

      Brown, E. L., Below, J. E., Fischer, R. S. B., Essigmann, H. T., Hu, H., Huff, C., Robinson, D. A., Petty, L. E., Aguilar, D., Bell, G. I. & Hanis, C. L., Nov 1 2015, In: PloS one. 10, 11, e0142130.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      16 Scopus citations

    • Genomic Analysis of Natural Selection and Phenotypic Variation in High-Altitude Mongolians

      Xing, J., Wuren, T., Simonson, T. S., Watkins, W. S., Witherspoon, D. J., Wu, W., Qin, G., Huff, C. D., Jorde, L. B. & Ge, R. L., Jul 2013, In: PLoS genetics. 9, 7, e1003634.

      Research output: Contribution to journal › Article › peer-review

      43 Scopus citations

    • Genomic diversity and evolution of the head crest in the rock pigeon

      Shapiro, M. D., Kronenberg, Z., Li, C., Domyan, E. T., Pan, H., Campbell, M., Tan, H., Huff, C. D., Hu, H., Vickrey, A. I., Nielsen, S. C. A., Stringham, S. A., Hu, H., Willerslev, E., Gilbert, M. T. P., Yandell, M., Zhang, G. & Wang, J., Mar 1 2013, In: Science. 339, 6123, p. 1063-1067 5 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      202 Scopus citations

    • Germline genetic variants and pediatric rhabdomyosarcoma outcomes: a report from the Children's Oncology Group

      Martin-Giacalone, B. A., Richard, M. A., Scheurer, M. E., Khan, J., Sok, P., Shetty, P. B., Chanock, S. J., Li, S. A., Yeager, M., Marquez-Do, D. A., Barkauskas, D. A., Hall, D., McEvoy, M. T., Brown, A. L., Sabo, A., Scheet, P., Huff, C. D., Skapek, S. X., Hawkins, D. S., Venkatramani, R., & 2 othersMirabello, L. & Lupo, P. J., Jun 8 2023, In: Journal of the National Cancer Institute. 115, 6, p. 733-741 9 p.

      Research output: Contribution to journal › Article › peer-review

      2 Scopus citations

    • Germline Sequencing Analysis to Inform Clinical Gene Panel Testing for Aggressive Prostate Cancer

      Darst, B. F., Saunders, E., Dadaev, T., Sheng, X., Wan, P., Pooler, L., Xia, L. Y., Chanock, S., Berndt, S. I., Wang, Y., Patel, A. V., Albanes, D., Weinstein, S. J., Gnanapragasam, V., Huff, C., Couch, F. J., Wolk, A., Giles, G. G., Nguyen-Dumont, T., Milne, R. L., & 17 othersPomerantz, M. M., Schmidt, J. A., Travis, R. C., Key, T. J., Stopsack, K. H., Mucci, L. A., Catalona, W. J., Marosy, B., Hetrick, K. N., Doheny, K. F., Macinnis, R. J., Southey, M. C., Eeles, R. A., Wiklund, F., Conti, D. V., Kote-Jarai, Z. & Haiman, C. A., Nov 16 2023, In: JAMA Oncology. 9, 11, p. 1514-1524 11 p.

      Research output: Contribution to journal › Article › peer-review

      2 Scopus citations

    • Global methylation of blood leukocyte DNA and risk of melanoma

      Shen, J., Song, R., Wan, J., Huff, C., Fang, S., Lee, J. E. & Zhao, H., Apr 1 2017, In: International journal of cancer. 140, 7, p. 1503-1509 7 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      10 Scopus citations

    • Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies

      Tu, J., Huo, Z., Yu, Y., Zhu, D., Xu, A., Huang, M. F., Hu, R., Wang, R., Gingold, J. A., Chen, Y. H., Tsai, K. L., Forcioli-Conti, N. R., Huang, S. X. L., Webb, T. R., Su, J., Bazer, D. A., Jia, P., Yustein, J. T., Wang, L. L., Hung, M. C., & 5 othersZhao, Z., Huff, C. D., Shen, J., Zhao, R. & Lee, D. F., Apr 19 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 16, 2117857119.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      12 Scopus citations