Research output per year
Research output per year
Research output
- 14 Article
- 14 results
Search results
-
2016
Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor
Palmer, W. S., Poncet-Montange, G., Liu, G., Petrocchi, A., Reyna, N., Subramanian, G., Theroff, J., Yau, A., Kost-Alimova, M., Bardenhagen, J. P., Leo, E., Shepard, H. E., Tieu, T. N., Shi, X., Zhan, Y., Zhao, S., Barton, M. C., Draetta, G., Toniatti, C., Jones, P., & 2 others, Feb 25 2016, In: Journal of Medicinal Chemistry. 59, 4, p. 1440-1454 15 p.Research output: Contribution to journal › Article › peer-review
Open Access119 Scopus citations -
2015
Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2
Poncet-Montange, G., Zhan, Y., Bardenhagen, J. P., Petrocchi, A., Leo, E., Shi, X., Lee, G. R., Leonard, P. G., Geck Do, M. K., Cardozo, M. G., Andersen, J. N., Palmer, W. S., Jones, P. & Ladbury, J. E., Mar 1 2015, In: Biochemical Journal. 466, p. 337-346 10 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
The SMARCA2/4 ATPase domain surpasses the bromodomain as a drug target in SWI/SNF-mutant cancers: Insights from cDNA rescue and PFI-3 inhibitor studies
Vangamudi, B., Paul, T. A., Shah, P. K., Kost-Alimova, M., Nottebaum, L., Shi, X., Zhan, Y., Leo, E., Mahadeshwar, H. S., Protopopov, A., Futreal, A., Tieu, T. N., Peoples, M., Heffernan, T. P., Marszalek, J. R., Toniatti, C., Petrocchi, A., Verhelle, D., Owen, D. R., Draetta, G., & 4 others, Sep 15 2015, In: Cancer Research. 75, 18, p. 3865-3878 14 p.Research output: Contribution to journal › Article › peer-review
Open Access182 Scopus citations -
2014
Therapeutic delivery of mir-200c enhances radiosensitivity in lung cancer
Cortez, M. A., Valdecanas, D., Zhang, X., Zhan, Y., Bhardwaj, V., Calin, G. A., Komaki, R., Giri, D. K., Quini, C. C., Wolfe, T., Peltier, H. J., Bader, A. G., Heymach, J. V., Meyn, R. E. & Welsh, J. W., Aug 2014, In: Molecular Therapy. 22, 8, p. 1494-1503 10 p.Research output: Contribution to journal › Article › peer-review
176 Scopus citations -
2012
C-met inhibitor MK-8003 radiosensitizes c-met-expressing non-small-cell lung cancer cells with radiation-induced c-met-expression
Bhardwaj, V., Zhan, Y., Cortez, M. A., Ang, K. K., Molkentine, D., Munshi, A., Raju, U., Komaki, R., Heymach, J. V. & Welsh, J., Aug 2012, In: Journal of Thoracic Oncology. 7, 8, p. 1211-1217 7 p.Research output: Contribution to journal › Article › peer-review
40 Scopus citations -
2011
Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative responses of neurotensin in human colonic epithelial cells
Zhao, D., Bakirtzi, K., Zhan, Y., Zeng, H., Koon, H. W. & Pothoulakis, C., Feb 25 2011, In: Journal of Biological Chemistry. 286, 8, p. 6092-6099 8 p.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
2008
Control of cell growth and survival by enzymes of the fatty acid synthesis pathway in HCT-116 colon cancer cells
Zhan, Y., Ginanni, N., Tota, M. R., Wu, M., Bays, N. W., Richon, V. M., Kohl, N. E., Bachman, E. S., Strack, P. R. & Krauss, S., Sep 15 2008, In: Clinical Cancer Research. 14, 18, p. 5735-5742 8 p.Research output: Contribution to journal › Article › peer-review
53 Scopus citations -
2007
Neurotensin stimulates expression of early growth response gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cells
Zhao, D., Zhan, Y., Zeng, H., Koon, H. W., Moyer, M. P. & Pothoulakis, C., Apr 15 2007, In: International journal of cancer. 120, 8, p. 1652-1656 5 p.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
Substance P mediates antiapoptotic responses in human colonocytes by Akt activation
Koon, H. W., Zhao, D., Zhan, Y., Moyer, M. P. & Pothoulakis, C., Feb 6 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 6, p. 2013-2018 6 p.Research output: Contribution to journal › Article › peer-review
93 Scopus citations -
2006
Ghrelin stimulates interleukin-8 gene expression through protein kinase C-mediated NF-κB pathway in human colonic epithelial cells
Zhao, D., Zhan, Y., Zeng, H., Moyer, M. P., Mantzoros, C. S. & Pothoulakis, C., Apr 15 2006, In: Journal of cellular biochemistry. 97, 6, p. 1317-1327 11 p.Research output: Contribution to journal › Article › peer-review
55 Scopus citations -
Substance P stimulates cyclooxygenase-2 and prostaglandin E2 expression through JAK-STAT activation in human colonic epithelial cells
Koon, H. W., Zhao, D., Zhan, Y., Rhee, S. H., Moyer, M. P. & Pothoulakis, C., Apr 15 2006, In: Journal of Immunology. 176, 8, p. 5050-5059 10 p.Research output: Contribution to journal › Article › peer-review
Open Access93 Scopus citations -
2005
Neurotensin stimulates interleukin-8 expression through modulation of IκBα phosphorylation and p65 transcriptional activity: Involvement of protein kinase Cα
Zhao, D., Zhan, Y., Zeng, H., Koon, H. W., Moyer, M. P. & Pothoulakis, C., Jun 2005, In: Molecular Pharmacology. 67, 6, p. 2025-2031 7 p.Research output: Contribution to journal › Article › peer-review
43 Scopus citations -
Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves protein kinase Cδ activation
Koon, H. W., Zhao, D., Zhan, Y., Simeonidis, S., Moyer, M. P. & Pothoulakis, C., Sep 2005, In: Journal of Pharmacology and Experimental Therapeutics. 314, 3, p. 1393-1400 8 p.Research output: Contribution to journal › Article › peer-review
61 Scopus citations -
2004
Metalloproteinase-dependent transforming growth factor-α release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells
Zhao, D., Zhan, Y., Hon, W. K., Zeng, H., Keates, S., Moyer, M. P. & Pothoulakis, C., Oct 15 2004, In: Journal of Biological Chemistry. 279, 42, p. 43547-43554 8 p.Research output: Contribution to journal › Article › peer-review
Open Access57 Scopus citations