TY - JOUR
T1 - α-enolase
T2 - A promising therapeutic and diagnostic tumor target
AU - Capello, Michela
AU - Ferri-Borgogno, Sammy
AU - Cappello, Paola
AU - Novelli, Francesco
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/4
Y1 - 2011/4
N2 - α-enolase (ENOA) is a metabolic enzyme involved in the synthesis of pyruvate. It also acts as a plasminogen receptor and thus mediates activation of plasmin and extracellular matrix degradation. In tumor cells, ENOA is upregulated and supports anaerobic proliferation (Warburg effect), it is expressed at the cell surface, where it promotes cancer invasion, and is subjected to a specific array of post-translational modifications, namely acetylation, methylation and phosphorylation. Both ENOA overexpression and its post-translational modifications could be of diagnostic and prognostic value in cancer. This review will discuss recent information on the biochemical, proteomics and immunological characterization of ENOA, particularly its ability to trigger a specific humoral and cellular immune response. In our opinion, this information can pave the way for effective new therapeutic and diagnostic strategies to counteract the growth of the most aggressive human disease.
AB - α-enolase (ENOA) is a metabolic enzyme involved in the synthesis of pyruvate. It also acts as a plasminogen receptor and thus mediates activation of plasmin and extracellular matrix degradation. In tumor cells, ENOA is upregulated and supports anaerobic proliferation (Warburg effect), it is expressed at the cell surface, where it promotes cancer invasion, and is subjected to a specific array of post-translational modifications, namely acetylation, methylation and phosphorylation. Both ENOA overexpression and its post-translational modifications could be of diagnostic and prognostic value in cancer. This review will discuss recent information on the biochemical, proteomics and immunological characterization of ENOA, particularly its ability to trigger a specific humoral and cellular immune response. In our opinion, this information can pave the way for effective new therapeutic and diagnostic strategies to counteract the growth of the most aggressive human disease.
KW - cancer
KW - immune response
KW - post-translational modifications
KW - tumor-associated antigen
KW - α-enolase
UR - http://www.scopus.com/inward/record.url?scp=79952830765&partnerID=8YFLogxK
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U2 - 10.1111/j.1742-4658.2011.08025.x
DO - 10.1111/j.1742-4658.2011.08025.x
M3 - Review article
C2 - 21261815
AN - SCOPUS:79952830765
SN - 1742-464X
VL - 278
SP - 1064
EP - 1074
JO - FEBS Journal
JF - FEBS Journal
IS - 7
ER -