β-catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression

Shiaw Yih Lin; Weiya Xia; Jo C. Wang; Ka Yin Kwong; Bill Spohn; Yong Wen; Richard G. Pestell; Mien Chie Hung

doi:10.1073/pnas.060025397

β-catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression

Shiaw Yih Lin, Weiya Xia, Jo C. Wang, Ka Yin Kwong, Bill Spohn, Yong Wen, Richard G. Pestell, Mien Chie Hung

Research output: Contribution to journal › Article › peer-review

695 Scopus citations

Abstract

β-Catenin can function as an oncogene when it is translocated to the nucleus, binds to T cell factor or lymphoid enhancer factor family members, and transactivates its target genes. In this study, we demonstrate that cyclin D1 is one of the targets of β-catenin in breast cancer cells. Transactivation of β-catenin correlated significantly with cyclin D1 expression both in eight breast cell lines in vitro and in 123 patient samples. More importantly, we found that high β-catenin activity significantly correlated with poor prognosis of the patients and was a strong and independent prognostic factor in breast cancer. Our studies, therefore, indicated that β-catenin can be involved in breast cancer formation and/or progression and may serve as a target for breast cancer therapy.

Original language	English (US)
Pages (from-to)	4262-4266
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	97
Issue number	8
DOIs	https://doi.org/10.1073/pnas.060025397
State	Published - Apr 11 2000

ASJC Scopus subject areas

General

Access to Document

10.1073/pnas.060025397

Cite this

@article{8e7764957f24492595a9a6adbf5d5b15,

title = "β-catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression",

abstract = "β-Catenin can function as an oncogene when it is translocated to the nucleus, binds to T cell factor or lymphoid enhancer factor family members, and transactivates its target genes. In this study, we demonstrate that cyclin D1 is one of the targets of β-catenin in breast cancer cells. Transactivation of β-catenin correlated significantly with cyclin D1 expression both in eight breast cell lines in vitro and in 123 patient samples. More importantly, we found that high β-catenin activity significantly correlated with poor prognosis of the patients and was a strong and independent prognostic factor in breast cancer. Our studies, therefore, indicated that β-catenin can be involved in breast cancer formation and/or progression and may serve as a target for breast cancer therapy.",

author = "Lin, {Shiaw Yih} and Weiya Xia and Wang, {Jo C.} and Kwong, {Ka Yin} and Bill Spohn and Yong Wen and Pestell, {Richard G.} and Hung, {Mien Chie}",

note = "Funding Information: This material is based on work supported by Science Foundation Ireland under Grant 00/PI.1/C075. We thank Brahim Hnich for his helpful comments.",

year = "2000",

month = apr,

day = "11",

doi = "10.1073/pnas.060025397",

language = "English (US)",

volume = "97",

pages = "4262--4266",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "8",

}

TY - JOUR

T1 - β-catenin, a novel prognostic marker for breast cancer

T2 - Its roles in cyclin D1 expression and cancer progression

AU - Lin, Shiaw Yih

AU - Xia, Weiya

AU - Wang, Jo C.

AU - Kwong, Ka Yin

AU - Spohn, Bill

AU - Wen, Yong

AU - Pestell, Richard G.

AU - Hung, Mien Chie

N1 - Funding Information: This material is based on work supported by Science Foundation Ireland under Grant 00/PI.1/C075. We thank Brahim Hnich for his helpful comments.

PY - 2000/4/11

Y1 - 2000/4/11

N2 - β-Catenin can function as an oncogene when it is translocated to the nucleus, binds to T cell factor or lymphoid enhancer factor family members, and transactivates its target genes. In this study, we demonstrate that cyclin D1 is one of the targets of β-catenin in breast cancer cells. Transactivation of β-catenin correlated significantly with cyclin D1 expression both in eight breast cell lines in vitro and in 123 patient samples. More importantly, we found that high β-catenin activity significantly correlated with poor prognosis of the patients and was a strong and independent prognostic factor in breast cancer. Our studies, therefore, indicated that β-catenin can be involved in breast cancer formation and/or progression and may serve as a target for breast cancer therapy.

AB - β-Catenin can function as an oncogene when it is translocated to the nucleus, binds to T cell factor or lymphoid enhancer factor family members, and transactivates its target genes. In this study, we demonstrate that cyclin D1 is one of the targets of β-catenin in breast cancer cells. Transactivation of β-catenin correlated significantly with cyclin D1 expression both in eight breast cell lines in vitro and in 123 patient samples. More importantly, we found that high β-catenin activity significantly correlated with poor prognosis of the patients and was a strong and independent prognostic factor in breast cancer. Our studies, therefore, indicated that β-catenin can be involved in breast cancer formation and/or progression and may serve as a target for breast cancer therapy.

UR - http://www.scopus.com/inward/record.url?scp=0034636153&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034636153&partnerID=8YFLogxK

U2 - 10.1073/pnas.060025397

DO - 10.1073/pnas.060025397

M3 - Article

C2 - 10759547

AN - SCOPUS:0034636153

SN - 0027-8424

VL - 97

SP - 4262

EP - 4266

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 8

ER -

β-catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this