β-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation

Markus Morkel, Joerg Huelsken, Maki Wakamiya, Jixiang Ding, Marc van de Wetering, Hans Clevers, Makoto M. Taketo, Richard R. Behringer, Michael M. Shen, Walter Birchmeier

Research output: Contribution to journalReview article

137 Scopus citations

Abstract

Gene expression profiling of β-catenin, Cripto and Wnt3 mutant mouse embryos has been used to characterise the genetic networks that regulate early embryonic development. We have defined genes whose expression is regulated by β-catenin during formation of the anteroposterior axis and the mesoderm, and have identified Cripto, which encodes a Nodal co-receptor, as a primary target of β-catenin signals both in embryogenesis as well as in colon carcinoma cell lines and tissues. We have also defined groups of genes regulated by Wnt3/β-catenin signalling during primitive streak and mesoderm formation. Our data assign a key role to β-catenin upstream of two distinct gene expression programs during anteroposterior axis and mesoderm formation.

Original languageEnglish (US)
Pages (from-to)6283-6294
Number of pages12
JournalDevelopment
Volume130
Issue number25
DOIs
StatePublished - Dec 1 2003

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Keywords

  • Anteroposterior axis
  • Gastrulation
  • Microarray
  • Nanog
  • Signalling pathways
  • Tdgf1

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

Cite this

Morkel, M., Huelsken, J., Wakamiya, M., Ding, J., van de Wetering, M., Clevers, H., Taketo, M. M., Behringer, R. R., Shen, M. M., & Birchmeier, W. (2003). β-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Development, 130(25), 6283-6294. https://doi.org/10.1242/dev.00859