β-cell death during progression to diabetes

Diane Mathis; Luis Vence; Christophe Benoist

doi:10.1038/414792a

β-cell death during progression to diabetes

Diane Mathis, Luis Vence, Christophe Benoist

Melanoma Medical Oncology

Research output: Contribution to journal › Review article › peer-review

782 Scopus citations

Abstract

The hallmark of type 1 diabetes is specific destruction of pancreatic islet β-cells. Apoptosis of β-cells may be crucial at several points during disease progression, initiating leukocyte invasion of the islets and terminating the production of insulin in islet cells. β-Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes.

Original language	English (US)
Pages (from-to)	792-798
Number of pages	7
Journal	Nature
Volume	414
Issue number	6865
DOIs	https://doi.org/10.1038/414792a
State	Published - Dec 13 2001

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title = "β-cell death during progression to diabetes",

abstract = "The hallmark of type 1 diabetes is specific destruction of pancreatic islet β-cells. Apoptosis of β-cells may be crucial at several points during disease progression, initiating leukocyte invasion of the islets and terminating the production of insulin in islet cells. β-Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes.",

author = "Diane Mathis and Luis Vence and Christophe Benoist",

note = "Funding Information: We apologize to the many investigators whose work we could not cite due to a limit on the number of references. We thank C. R. Kahn for his insights into type 2 diabetes. Our work on b-cell death is funded by a research grant from the Juvenile Diabetes Research Foundation.",

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doi = "10.1038/414792a",

language = "English (US)",

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T1 - β-cell death during progression to diabetes

AU - Mathis, Diane

AU - Vence, Luis

AU - Benoist, Christophe

N1 - Funding Information: We apologize to the many investigators whose work we could not cite due to a limit on the number of references. We thank C. R. Kahn for his insights into type 2 diabetes. Our work on b-cell death is funded by a research grant from the Juvenile Diabetes Research Foundation.

PY - 2001/12/13

Y1 - 2001/12/13

N2 - The hallmark of type 1 diabetes is specific destruction of pancreatic islet β-cells. Apoptosis of β-cells may be crucial at several points during disease progression, initiating leukocyte invasion of the islets and terminating the production of insulin in islet cells. β-Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes.

AB - The hallmark of type 1 diabetes is specific destruction of pancreatic islet β-cells. Apoptosis of β-cells may be crucial at several points during disease progression, initiating leukocyte invasion of the islets and terminating the production of insulin in islet cells. β-Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes.

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DO - 10.1038/414792a

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JF - Nature

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ER -

β-cell death during progression to diabetes

Abstract

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