β-Lactamase-Responsive Probe for Efficient Photodynamic Therapy of Drug-Resistant Bacterial Infection

Yue Xu, Haiyan Chen, Shufen Xu, Ji Liu, Yang Chen, Lijuan Gui, Hua Li, Ruixi Li, Zhenwei Yuan, Bowen Li

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Several photosensitizers have recently been proposed as novel approaches against β-lactamase-producing drug-resistant bacteria. However, these reported photosensitizers are rarely used for accurate recognition of drug-resistant bacteria. To tackle this challenge, the structurally modified photosensitizer CySG-2 based on a lipophilic cationic heptamethine indocyanine near-infrared (NIR) dye (IR-780) and an important synthesis intermediate of cephalosporin antibiotic (GCLE) not only achieved the accurate recognition of TEM-1 methicillin-resistant Staphylococcus aureus (MRSA) successfully but also achieved antimicrobial photodynamic therapy (aPDT) in animal models infected by drug-resistant bacteria. Accurate enzyme recognition and efficient photodynamic therapy capabilities allow CySG-2 to achieve one stone with two birds. In addition, CySG-2 could also promote the eradication of internalized MRSA by facilitating the autophagy process, which is synergistic with its capacity of inducing reactive oxygen species generation under NIR laser irradiation for aPDT. Collectively, it is an effective multifunctional photosensitizer with the potential ability to guide the optimal use of different antibiotics and apply them in clinical treatment.

Original languageEnglish (US)
Pages (from-to)1361-1371
Number of pages11
JournalACS Sensors
Volume7
Issue number5
DOIs
StatePublished - May 27 2022

Keywords

  • antibacterial photodynamic therapy
  • internalized bacterial autophagy
  • MRSA
  • photosensitizers
  • reactive oxygen species

ASJC Scopus subject areas

  • Bioengineering
  • Instrumentation
  • Process Chemistry and Technology
  • Fluid Flow and Transfer Processes

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