TY - JOUR
T1 - β‐Lactam regimens for the febrile neutropenic patient
AU - Bodey, Gerald P.
AU - Fainstein, Victor
AU - Elting, Linda S.
AU - Anaissie, Elias
AU - Rolston, Kenneth
AU - Khardori, Nancy
AU - Kantarjian, Hagop
AU - Plager, Carl
AU - Murphy, William K.
AU - Holmes, Frankie
AU - Cabanillas, Fernando
PY - 1990/1/1
Y1 - 1990/1/1
N2 - A total of 535 evaluable febrile episodes in neutropenic patients were randomly assigned to treatment with ticarcillin‐clavulanate plus vancomycin (TV), ceftazidime plus vancomycin (CV), or all three antibiotics (TCV). The TCV regimen was significantly more effective than TV, considering all evaluable episodes, documented infections, gram‐negative infections, and infections in patients with persistent severe neutropenia (< 100 neutrophils/mm3). The results with CV were intermediate between TV and TCV. The toxicities were similar with all three regimens and consisted primarily of skin rashes. The TCV regimen is effective for empiric therapy of fever in neutropenic patients and probably should be utilized in preference to CV or TV, although its superiority over CV in this study was inconclusive.
AB - A total of 535 evaluable febrile episodes in neutropenic patients were randomly assigned to treatment with ticarcillin‐clavulanate plus vancomycin (TV), ceftazidime plus vancomycin (CV), or all three antibiotics (TCV). The TCV regimen was significantly more effective than TV, considering all evaluable episodes, documented infections, gram‐negative infections, and infections in patients with persistent severe neutropenia (< 100 neutrophils/mm3). The results with CV were intermediate between TV and TCV. The toxicities were similar with all three regimens and consisted primarily of skin rashes. The TCV regimen is effective for empiric therapy of fever in neutropenic patients and probably should be utilized in preference to CV or TV, although its superiority over CV in this study was inconclusive.
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U2 - 10.1002/1097-0142(19900101)65:1<9::AID-CNCR2820650105>3.0.CO;2-C
DO - 10.1002/1097-0142(19900101)65:1<9::AID-CNCR2820650105>3.0.CO;2-C
M3 - Article
C2 - 2403484
AN - SCOPUS:0025020675
SN - 0008-543X
VL - 65
SP - 9
EP - 16
JO - Cancer
JF - Cancer
IS - 1
ER -