γδ T-cell development

James P. Allison

doi:10.1016/0952-7915(93)90011-G

γδ T-cell development

James P. Allison

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

γδ T cells consist of multiple lineages of cells with distinct antigen receptor repertoires, tissue localization and function. Recent evidence suggests that the ordered appearance of these sublineages during development is a result of programed rearrangement of Vy-gene segments. It appears that the T-cell receptor repertoire, at least of the γδ T cells with invariant receptors, is the result of site-directed rearrangement and cellular selection does not play a major role.

Original language	English (US)
Pages (from-to)	241-246
Number of pages	6
Journal	Current Opinion in Immunology
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/0952-7915(93)90011-G
State	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/0952-7915(93)90011-G

Cite this

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title = "γδ T-cell development",

abstract = "γδ T cells consist of multiple lineages of cells with distinct antigen receptor repertoires, tissue localization and function. Recent evidence suggests that the ordered appearance of these sublineages during development is a result of programed rearrangement of Vy-gene segments. It appears that the T-cell receptor repertoire, at least of the γδ T cells with invariant receptors, is the result of site-directed rearrangement and cellular selection does not play a major role.",

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AB - γδ T cells consist of multiple lineages of cells with distinct antigen receptor repertoires, tissue localization and function. Recent evidence suggests that the ordered appearance of these sublineages during development is a result of programed rearrangement of Vy-gene segments. It appears that the T-cell receptor repertoire, at least of the γδ T cells with invariant receptors, is the result of site-directed rearrangement and cellular selection does not play a major role.

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U2 - 10.1016/0952-7915(93)90011-G

DO - 10.1016/0952-7915(93)90011-G

M3 - Article

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γδ T-cell development

Abstract

ASJC Scopus subject areas

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