γ-AApeptides: Design, synthesis and evaluation

Youhong Niu; Yaogang Hu; Xiaolong Li; Jiandong Chen; Jianfeng Cai

doi:10.1039/c0nj00943a

γ-AApeptides: Design, synthesis and evaluation

Youhong Niu, Yaogang Hu, Xiaolong Li, Jiandong Chen, Jianfeng Cai

Neuro-Oncology

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

A new class of peptide mimics termed "γ-AApeptides" has been described. The design and synthesis of γ-AApeptides, and potential bioactivities towards p53/MDM2 interaction were demonstrated. γ-AApeptides were also found to be highly resistant to proteolysis. The development of sequence-specific γ-AApeptides may lead to a family of peptidomimetics with a new framework for drug discovery or peptide/protein mimicry.

Original language	English (US)
Pages (from-to)	542-545
Number of pages	4
Journal	New Journal of Chemistry
Volume	35
Issue number	3
DOIs	https://doi.org/10.1039/c0nj00943a
State	Published - Mar 2011

ASJC Scopus subject areas

Catalysis
General Chemistry
Materials Chemistry

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author = "Youhong Niu and Yaogang Hu and Xiaolong Li and Jiandong Chen and Jianfeng Cai",

year = "2011",

month = mar,

doi = "10.1039/c0nj00943a",

language = "English (US)",

volume = "35",

pages = "542--545",

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T2 - Design, synthesis and evaluation

AU - Niu, Youhong

AU - Hu, Yaogang

AU - Li, Xiaolong

AU - Chen, Jiandong

AU - Cai, Jianfeng

PY - 2011/3

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AB - A new class of peptide mimics termed "γ-AApeptides" has been described. The design and synthesis of γ-AApeptides, and potential bioactivities towards p53/MDM2 interaction were demonstrated. γ-AApeptides were also found to be highly resistant to proteolysis. The development of sequence-specific γ-AApeptides may lead to a family of peptidomimetics with a new framework for drug discovery or peptide/protein mimicry.

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γ-AApeptides: Design, synthesis and evaluation

Abstract

ASJC Scopus subject areas

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