14-Esters of 7-O-(3,4-DI-O-Acetyl-2,6-Dideoxy-α-L-L Yxo-Hexopyranosyl)adriamycinone: Synthesis and antitumor activity

Derek Horton; Waldemar Priebe

doi:10.7164/antibiotics.36.1211

14-Esters of 7-O-(3,4-DI-O-Acetyl-2,6-Dideoxy-α-L-L Yxo-Hexopyranosyl)adriamycinone: Synthesis and antitumor activity

Derek Horton, Waldemar Priebe

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A range of 14-esters (8~13) of the title compound, 3’-deamino-3’-hydroxydoxorubicin 3’,4’-diacetate (5), has been synthesized by nucleophilic substitution of the corresponding 14-bromide (6) by the appropriate sodium carboxylate salts. Antitumor activities were determined in vivo in the murine P388 lymphocytic leukemia assay and compared with those of the 14-hydroxy and 14-acetoxy analogs.

Original language	English (US)
Pages (from-to)	1211-1215
Number of pages	5
Journal	The Journal of Antibiotics
Volume	36
Issue number	9
DOIs	https://doi.org/10.7164/antibiotics.36.1211
State	Published - Jan 1983
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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author = "Derek Horton and Waldemar Priebe",

year = "1983",

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doi = "10.7164/antibiotics.36.1211",

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AU - Horton, Derek

AU - Priebe, Waldemar

PY - 1983/1

Y1 - 1983/1

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AB - A range of 14-esters (8~13) of the title compound, 3’-deamino-3’-hydroxydoxorubicin 3’,4’-diacetate (5), has been synthesized by nucleophilic substitution of the corresponding 14-bromide (6) by the appropriate sodium carboxylate salts. Antitumor activities were determined in vivo in the murine P388 lymphocytic leukemia assay and compared with those of the 14-hydroxy and 14-acetoxy analogs.

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14-Esters of 7-O-(3,4-DI-O-Acetyl-2,6-Dideoxy-α-L-L Yxo-Hexopyranosyl)adriamycinone: Synthesis and antitumor activity

Abstract

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