TY - JOUR
T1 - 2-Chlorodeoxyadenosine therapy in patients with T-cell lymphoproliferative disorders
AU - O'Brien, Susan
AU - Kurzrock, Razelle
AU - Duvic, Madeleine
AU - Kantarjian, Hagop
AU - Stass, Stanford
AU - Robertson, L. E.
AU - Estey, Elihu
AU - Pierce, Sherry
AU - Keating, Michael J.
PY - 1994/8/1
Y1 - 1994/8/1
N2 - Mature T-cell lymphoproliferative disorders comprise a heterogenous group of diseases for which there is no standard therapy. These disorders are uncommon, and are usually treated similarly to their B-cell counterparts, but with less success. Nucleoside analogues have proven effective in indolent B- cell disorders but have been less well explored in T-cell malignancies. We treated 22 patients with mature T-cell lymphoproliferative diseases with 2- chlorodeoxyadenosine (2-CDA) administered as a continuous infusion at a daily dose of 4 mg/m2 over 7 days. Nineteen of the patients had received prior therapy with a median number of prior regimens of three. Eleven patients had leukemia or large granular lymphocytosis, eight patients had mycosis fungoides, and three had T-cell lymphoma. Nine patients (41%) responded to 2- CDA. Four of the patients had responses that were complete remissions, and three of these four patients remain in remission at 23, 24, and 33 months. The only important toxic effects were fever or infection, seen during 38% of courses. In conclusion, 2-CDA appears to be an effective therapy in T-cell lymphoproliferative disorders and deserves wider evaluation in this subset of patients.
AB - Mature T-cell lymphoproliferative disorders comprise a heterogenous group of diseases for which there is no standard therapy. These disorders are uncommon, and are usually treated similarly to their B-cell counterparts, but with less success. Nucleoside analogues have proven effective in indolent B- cell disorders but have been less well explored in T-cell malignancies. We treated 22 patients with mature T-cell lymphoproliferative diseases with 2- chlorodeoxyadenosine (2-CDA) administered as a continuous infusion at a daily dose of 4 mg/m2 over 7 days. Nineteen of the patients had received prior therapy with a median number of prior regimens of three. Eleven patients had leukemia or large granular lymphocytosis, eight patients had mycosis fungoides, and three had T-cell lymphoma. Nine patients (41%) responded to 2- CDA. Four of the patients had responses that were complete remissions, and three of these four patients remain in remission at 23, 24, and 33 months. The only important toxic effects were fever or infection, seen during 38% of courses. In conclusion, 2-CDA appears to be an effective therapy in T-cell lymphoproliferative disorders and deserves wider evaluation in this subset of patients.
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U2 - 10.1182/blood.v84.3.733.bloodjournal843733
DO - 10.1182/blood.v84.3.733.bloodjournal843733
M3 - Article
C2 - 7913841
AN - SCOPUS:0028272475
SN - 0006-4971
VL - 84
SP - 733
EP - 738
JO - Blood
JF - Blood
IS - 3
ER -