2-Deoxy-D-Glucose and its analogs: From diagnostic to therapeutic agents

B. Pajak, E. Siwiak, M. Sołtyka, A. Priebe, R. Zieliński, I. Fokt, M. Ziemniak, A. Jaśkiewicz, R. Borowski, T. Domoradzki, W. Priebe

Research output: Contribution to journalReview article

Abstract

The ability of 2-deoxy-d-glucose (2-DG) to interfere with d-glucose metabolism demonstrates that nutrient and energy deprivation is an efficient tool to suppress cancer cell growth and survival. Acting as a d-glucose mimic, 2-DG inhibits glycolysis due to formation and intracellular accumulation of 2-deoxy-d-glucose-6-phosphate (2-DG6P), inhibiting the function of hexokinase and glucose-6-phosphate isomerase, and inducing cell death. In addition to glycolysis inhibition, other molecular processes are also affected by 2-DG. Attempts to improve 2-DG’s drug-like properties, its role as a potential adjuvant for other chemotherapeutics, and novel 2-DG analogs as promising new anticancer agents are discussed in this review.

Original languageEnglish (US)
Article number234
JournalInternational journal of molecular sciences
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2020

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Keywords

  • 2-deoxy-d-glucose
  • 2-DG analogs
  • Anticancer therapy
  • Glioblastoma

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Pajak, B., Siwiak, E., Sołtyka, M., Priebe, A., Zieliński, R., Fokt, I., Ziemniak, M., Jaśkiewicz, A., Borowski, R., Domoradzki, T., & Priebe, W. (2020). 2-Deoxy-D-Glucose and its analogs: From diagnostic to therapeutic agents. International journal of molecular sciences, 21(1), [234]. https://doi.org/10.3390/ijms21010234