Abstract
3’-Deamino-4’-epi-3’-hydroxy-daunorubicin (11) and -doxorubicin (14) have been synthesized. In the in vivo murine P-388 lymphocytic leukemia assay, these two compounds were more active than daunorubicin (1) and doxorubicin (2), respectively. Comparative studies in the P-388 assay indicated 3’-deamino-3’-hydroxydoxorubicin (3) to be more active than its 4’-epimer 14.
Original language | English (US) |
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Pages (from-to) | 1635-1641 |
Number of pages | 7 |
Journal | Journal of Antibiotics |
Volume | 37 |
Issue number | 12 |
DOIs | |
State | Published - Jan 1984 |
Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery