TY - JOUR
T1 - 3D Chromosomal Landscapes in Hematopoiesis and Immunity
AU - Kloetgen, Andreas
AU - Thandapani, Palaniraja
AU - Tsirigos, Aristotelis
AU - Aifantis, Iannis
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/9
Y1 - 2019/9
N2 - Epigenetic dysregulation plays a profound role in the pathogenesis of hematological malignancies, which is often the result of somatic mutations of chromatin regulators. Previously, these mutations were largely considered to alter gene expression in two dimensions, by activating or repressing chromatin states; however, research in the last decade has highlighted the increasing impact of the 3D organization of the genome in gene regulation and disease pathogenesis. Here, we summarize the current principles of 3D chromatin organization, how the integrity of the 3D genome governs immune cell development and malignant transformation, as well as how underlying (epi-)genetic drivers of 3D chromatin alterations might act as potential novel therapeutic targets for hematological malignancies.
AB - Epigenetic dysregulation plays a profound role in the pathogenesis of hematological malignancies, which is often the result of somatic mutations of chromatin regulators. Previously, these mutations were largely considered to alter gene expression in two dimensions, by activating or repressing chromatin states; however, research in the last decade has highlighted the increasing impact of the 3D organization of the genome in gene regulation and disease pathogenesis. Here, we summarize the current principles of 3D chromatin organization, how the integrity of the 3D genome governs immune cell development and malignant transformation, as well as how underlying (epi-)genetic drivers of 3D chromatin alterations might act as potential novel therapeutic targets for hematological malignancies.
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U2 - 10.1016/j.it.2019.07.003
DO - 10.1016/j.it.2019.07.003
M3 - Review article
C2 - 31422902
AN - SCOPUS:85070536425
SN - 1471-4906
VL - 40
SP - 809
EP - 824
JO - Trends in Immunology
JF - Trends in Immunology
IS - 9
ER -