5-azacytidine and arabinosyl adenine for the treatment of acute leukemia

Gerald P. Bodey; Kenneth B. McCredie; Jeane P. Hester; Emil J. Freireich

doi:10.1016/0145-2126(77)90043-1

5-azacytidine and arabinosyl adenine for the treatment of acute leukemia

Gerald P. Bodey, Kenneth B. McCredie, Jeane P. Hester, Emil J. Freireich

Leukemia

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The combination of 5-azacytidine and arabinosyl cytosine was used as secondary treatment for patients with acute leukemia. Only five of 39 evaluable patients achieved a complete remission, although 15 patients showed some response to this therapy. The median duration of complete remission was only 3 3 4 months. Major toxicity included myelosuppression, nausea, vomiting and diarrhea. The results of this study were no better than those obtained previously with 5-azacytidine alone.

Original language	English (US)
Pages (from-to)	257-260
Number of pages	4
Journal	Leukemia Research
Volume	1
Issue number	4
DOIs	https://doi.org/10.1016/0145-2126(77)90043-1
State	Published - 1977

Keywords

5-azacytidine
Acute leukemia
adenine
arabinosyl
cancer chemotherapy

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/0145-2126(77)90043-1

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title = "5-azacytidine and arabinosyl adenine for the treatment of acute leukemia",

abstract = "The combination of 5-azacytidine and arabinosyl cytosine was used as secondary treatment for patients with acute leukemia. Only five of 39 evaluable patients achieved a complete remission, although 15 patients showed some response to this therapy. The median duration of complete remission was only 3 3 4 months. Major toxicity included myelosuppression, nausea, vomiting and diarrhea. The results of this study were no better than those obtained previously with 5-azacytidine alone.",

keywords = "5-azacytidine, Acute leukemia, adenine, arabinosyl, cancer chemotherapy",

author = "Bodey, {Gerald P.} and McCredie, {Kenneth B.} and Hester, {Jeane P.} and Freireich, {Emil J.}",

note = "Funding Information: * Supported in part by Grants CA 05831, CA 19806, CA 11520, CA 10376 and CA 14528 from the National Cancer Institute, National Institutes of Health, U.S. Public Health Service, Bethesda, MD 20014, U.S.A.",

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language = "English (US)",

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T1 - 5-azacytidine and arabinosyl adenine for the treatment of acute leukemia

AU - Bodey, Gerald P.

AU - McCredie, Kenneth B.

AU - Hester, Jeane P.

AU - Freireich, Emil J.

N1 - Funding Information: * Supported in part by Grants CA 05831, CA 19806, CA 11520, CA 10376 and CA 14528 from the National Cancer Institute, National Institutes of Health, U.S. Public Health Service, Bethesda, MD 20014, U.S.A.

PY - 1977

Y1 - 1977

N2 - The combination of 5-azacytidine and arabinosyl cytosine was used as secondary treatment for patients with acute leukemia. Only five of 39 evaluable patients achieved a complete remission, although 15 patients showed some response to this therapy. The median duration of complete remission was only 3 3 4 months. Major toxicity included myelosuppression, nausea, vomiting and diarrhea. The results of this study were no better than those obtained previously with 5-azacytidine alone.

AB - The combination of 5-azacytidine and arabinosyl cytosine was used as secondary treatment for patients with acute leukemia. Only five of 39 evaluable patients achieved a complete remission, although 15 patients showed some response to this therapy. The median duration of complete remission was only 3 3 4 months. Major toxicity included myelosuppression, nausea, vomiting and diarrhea. The results of this study were no better than those obtained previously with 5-azacytidine alone.

KW - 5-azacytidine

KW - Acute leukemia

KW - adenine

KW - arabinosyl

KW - cancer chemotherapy

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5-azacytidine and arabinosyl adenine for the treatment of acute leukemia

Abstract

Keywords

ASJC Scopus subject areas

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