@article{dd5fe963ac0e4e048cc7ef6fed9fb169,
title = "A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells",
abstract = "p60 is a cellular protein that binds to the adenovirus E1A protein complex in virally infected or transformed human cells. In both infected and uninfected cells, p60 was found in a complex with the cdc2 protein kinase. Immune complexes containing p60 and cdc2 display a cell cycle-dependent histone H1 kinase activity that is most active in interphase. The previously described cdc2-p62/cyclin complex also acts as a histone H1 kinase but is maximally active in mitotic metaphase. The shift in the timing of activation of different cdc2-containing complexes suggests that each might play a distinct role in regulation of the cell cycle.",
author = "Antonio Giordano and Peter Whyte and Ed Harlow and Franza, {B. Robert} and David Beach and Giulio Draetta",
note = "Funding Information: We thank Linda Christy for technical assistance and Jim Duffy, Dave Green, and Phil Renna for help in preparation of the figures. 2-D gels were run by H. Sacco and A. Rudman in the Quest Gel Facility at CSHL. We are also grateful to Jon Pines and Tony Hunter for their gift of human anti-cyclin B serum. Betty Moran and Bruce Stillman are thanked for their comments on the manuscript. This work was supported by National Institutes of Health grants GM39620 (to D. B. and G. D.) and CA13106 (to E. H.) and by the Mellam Family Foundation and NlHlNlAlD grant PO1 Al27270 (to B. R. F.). A. G. was supported by a postdoctoral fellowship from Bristol Myers.",
year = "1989",
month = sep,
day = "8",
doi = "10.1016/0092-8674(89)90949-5",
language = "English (US)",
volume = "58",
pages = "981--990",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "5",
}