A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics

Miriam Meyer; Andrea Mahr; Joanna Brewer; Volker Daniel; Justine Dell‘Aringa; Tony Goldstone; Sarah Hersey; Ian Johnston; Pamela Larson; Michael Loveridge; Gavin MacBeath; Mark Moyer; Dirk Nagorsen; Sophie Papa; Leanne Peiser; Koustubh Ranade; Ruben Rizzi; Axel Roers; Dolores Schendel; Pallavur Sivakumar; Eric Tran; Özlem Türeci; Luise Weigand; Anders Wennborg; Dennis Williams; Cassian Yee; Cedrik M. Britten

doi:10.1038/d41573-023-00189-4

A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics

Miriam Meyer, Andrea Mahr, Joanna Brewer, Volker Daniel, Justine Dell‘Aringa, Tony Goldstone, Sarah Hersey, Ian Johnston, Pamela Larson, Michael Loveridge, Gavin MacBeath, Mark Moyer, Dirk Nagorsen, Sophie Papa, Leanne Peiser, Koustubh Ranade, Ruben Rizzi, Axel Roers, Dolores Schendel, Pallavur SivakumarEric Tran, Özlem Türeci, Luise Weigand, Anders Wennborg, Dennis Williams, Cassian Yee, Cedrik M. Britten

Melanoma Medical Oncology

Research output: Contribution to journal › Comment/debate › peer-review

1 Scopus citations

Abstract

Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on patients and the organizations developing these products. We propose regulatory flexibility to facilitate the development of and access to TCR-based therapeutics.

Original language	English (US)
Pages (from-to)	1-2
Number of pages	2
Journal	Nature Reviews Drug Discovery
Volume	23
Issue number	1
DOIs	https://doi.org/10.1038/d41573-023-00189-4
State	Published - Jan 2024

ASJC Scopus subject areas

Pharmacology
Drug Discovery

Access to Document

10.1038/d41573-023-00189-4

Cite this

Meyer, M., Mahr, A., Brewer, J., Daniel, V., Dell‘Aringa, J., Goldstone, T., Hersey, S., Johnston, I., Larson, P., Loveridge, M., MacBeath, G., Moyer, M., Nagorsen, D., Papa, S., Peiser, L., Ranade, K., Rizzi, R., Roers, A., Schendel, D., ... Britten, C. M. (2024). A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics. Nature Reviews Drug Discovery, 23(1), 1-2. https://doi.org/10.1038/d41573-023-00189-4

Meyer, M, Mahr, A, Brewer, J, Daniel, V, Dell‘Aringa, J, Goldstone, T, Hersey, S, Johnston, I, Larson, P, Loveridge, M, MacBeath, G, Moyer, M, Nagorsen, D, Papa, S, Peiser, L, Ranade, K, Rizzi, R, Roers, A, Schendel, D, Sivakumar, P, Tran, E, Türeci, Ö, Weigand, L, Wennborg, A, Williams, D, Yee, C & Britten, CM 2024, 'A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics', Nature Reviews Drug Discovery, vol. 23, no. 1, pp. 1-2. https://doi.org/10.1038/d41573-023-00189-4

@article{9ac6d328b86e4082a8810504998cca39,

title = "A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics",

abstract = "Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on patients and the organizations developing these products. We propose regulatory flexibility to facilitate the development of and access to TCR-based therapeutics.",

author = "Miriam Meyer and Andrea Mahr and Joanna Brewer and Volker Daniel and Justine Dell{\textquoteleft}Aringa and Tony Goldstone and Sarah Hersey and Ian Johnston and Pamela Larson and Michael Loveridge and Gavin MacBeath and Mark Moyer and Dirk Nagorsen and Sophie Papa and Leanne Peiser and Koustubh Ranade and Ruben Rizzi and Axel Roers and Dolores Schendel and Pallavur Sivakumar and Eric Tran and {\"O}zlem T{\"u}reci and Luise Weigand and Anders Wennborg and Dennis Williams and Cassian Yee and Britten, {Cedrik M.}",

note = "Publisher Copyright: {\textcopyright} 2023, Springer Nature Limited.",

year = "2024",

month = jan,

doi = "10.1038/d41573-023-00189-4",

language = "English (US)",

volume = "23",

pages = "1--2",

journal = "Nature Reviews Drug Discovery",

issn = "1474-1776",

publisher = "Nature Research",

number = "1",

}

TY - JOUR

T1 - A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics

AU - Meyer, Miriam

AU - Mahr, Andrea

AU - Brewer, Joanna

AU - Daniel, Volker

AU - Dell‘Aringa, Justine

AU - Goldstone, Tony

AU - Hersey, Sarah

AU - Johnston, Ian

AU - Larson, Pamela

AU - Loveridge, Michael

AU - MacBeath, Gavin

AU - Moyer, Mark

AU - Nagorsen, Dirk

AU - Papa, Sophie

AU - Peiser, Leanne

AU - Ranade, Koustubh

AU - Rizzi, Ruben

AU - Roers, Axel

AU - Schendel, Dolores

AU - Sivakumar, Pallavur

AU - Tran, Eric

AU - Türeci, Özlem

AU - Weigand, Luise

AU - Wennborg, Anders

AU - Williams, Dennis

AU - Yee, Cassian

AU - Britten, Cedrik M.

PY - 2024/1

Y1 - 2024/1

N2 - Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on patients and the organizations developing these products. We propose regulatory flexibility to facilitate the development of and access to TCR-based therapeutics.

AB - Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on patients and the organizations developing these products. We propose regulatory flexibility to facilitate the development of and access to TCR-based therapeutics.

UR - http://www.scopus.com/inward/record.url?scp=85177856964&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85177856964&partnerID=8YFLogxK

U2 - 10.1038/d41573-023-00189-4

DO - 10.1038/d41573-023-00189-4

M3 - Comment/debate

C2 - 38030734

AN - SCOPUS:85177856964

SN - 1474-1776

VL - 23

SP - 1

EP - 2

JO - Nature Reviews Drug Discovery

JF - Nature Reviews Drug Discovery

IS - 1

ER -

A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this