A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics

Miriam Meyer; Andrea Mahr; Joanna Brewer; Volker Daniel; Justine Dell‘Aringa; Tony Goldstone; Sarah Hersey; Ian Johnston; Pamela Larson; Michael Loveridge; Gavin MacBeath; Mark Moyer; Dirk Nagorsen; Sophie Papa; Leanne Peiser; Koustubh Ranade; Ruben Rizzi; Axel Roers; Dolores Schendel; Pallavur Sivakumar; Eric Tran; Özlem Türeci; Luise Weigand; Anders Wennborg; Dennis Williams; Cassian Yee; Cedrik M. Britten

doi:10.1038/d41573-023-00189-4

A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics

Miriam Meyer, Andrea Mahr, Joanna Brewer, Volker Daniel, Justine Dell‘Aringa, Tony Goldstone, Sarah Hersey, Ian Johnston, Pamela Larson, Michael Loveridge, Gavin MacBeath, Mark Moyer, Dirk Nagorsen, Sophie Papa, Leanne Peiser, Koustubh Ranade, Ruben Rizzi, Axel Roers, Dolores Schendel, Pallavur SivakumarEric Tran, Özlem Türeci, Luise Weigand, Anders Wennborg, Dennis Williams, Cassian Yee, Cedrik M. Britten

Melanoma Medical Oncology

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on patients and the organizations developing these products. We propose regulatory flexibility to facilitate the development of and access to TCR-based therapeutics.

Original language	English (US)
Pages (from-to)	1-2
Number of pages	2
Journal	Nature Reviews Drug Discovery
Volume	23
Issue number	1
DOIs	https://doi.org/10.1038/d41573-023-00189-4
State	Published - Jan 2024

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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Meyer, M., Mahr, A., Brewer, J., Daniel, V., Dell‘Aringa, J., Goldstone, T., Hersey, S., Johnston, I., Larson, P., Loveridge, M., MacBeath, G., Moyer, M., Nagorsen, D., Papa, S., Peiser, L., Ranade, K., Rizzi, R., Roers, A., Schendel, D., ... Britten, C. M. (2024). A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics. Nature Reviews Drug Discovery, 23(1), 1-2. https://doi.org/10.1038/d41573-023-00189-4

Meyer, M, Mahr, A, Brewer, J, Daniel, V, Dell‘Aringa, J, Goldstone, T, Hersey, S, Johnston, I, Larson, P, Loveridge, M, MacBeath, G, Moyer, M, Nagorsen, D, Papa, S, Peiser, L, Ranade, K, Rizzi, R, Roers, A, Schendel, D, Sivakumar, P, Tran, E, Türeci, Ö, Weigand, L, Wennborg, A, Williams, D, Yee, C & Britten, CM 2024, 'A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics', Nature Reviews Drug Discovery, vol. 23, no. 1, pp. 1-2. https://doi.org/10.1038/d41573-023-00189-4

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abstract = "Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on patients and the organizations developing these products. We propose regulatory flexibility to facilitate the development of and access to TCR-based therapeutics.",

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AU - Goldstone, Tony

AU - Hersey, Sarah

AU - Johnston, Ian

AU - Larson, Pamela

AU - Loveridge, Michael

AU - MacBeath, Gavin

AU - Moyer, Mark

AU - Nagorsen, Dirk

AU - Papa, Sophie

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AU - Sivakumar, Pallavur

AU - Tran, Eric

AU - Türeci, Özlem

AU - Weigand, Luise

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AU - Williams, Dennis

AU - Yee, Cassian

AU - Britten, Cedrik M.

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A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics

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