TY - JOUR
T1 - A Case-Control Study of Wood Dust Exposure, Mutagen Sensitivity, and Lung Cancer Risk
AU - Wu, Xifeng
AU - Bondy, Melissa L.
AU - Honn, Susan E.
AU - Henry, Betty
AU - Spitz, Margaret R.
PY - 1995/10/1
Y1 - 1995/10/1
N2 - The associations between lung cancer risk, mutagen sensitivity (a marker of cancer susceptibility), and a putative lung carcinogen, wood dust, were assessed in a hospital-based case-control study. There were 113 African-American and 67 Mexican-American cases with newly diagnosed, previously untreated lung cancer and 270 controls, frequency-matched on age, ethnicity, and sex. Mutagen sensitivity (1 chromatid break/cell after short-term bleomycin treatment) was associated with statistically significant elevated risk for lung cancer [odds ratio (OR) = 4.3; 95% confidence intervals (I = 2.37.9]. Wood dust exposure was also a significant predictor of risk (overall OR = 3.5; CI = 1.4-8.6) after controlling for smoking and mutagen sensitivity. When stratified by ethnicity, wood dust exposure was a significant risk factor for African-Americans (OR = 5.5; CI = 1.6-18.9) but not for Mexican-Americans (OR = 2.0; CI = 0.58.1). The ORs were 3.8 and 4.8 for non-small cell lung cancer in Mexican-Americans and African-Americans, respectively, but were only statistically significant for African-Americans (CI = 1.2-18.5). Stratified analysis suggested evidence of strong interactions between wood dust exposure and both mutagen sensitivity and smoking in lung cancer risk.
AB - The associations between lung cancer risk, mutagen sensitivity (a marker of cancer susceptibility), and a putative lung carcinogen, wood dust, were assessed in a hospital-based case-control study. There were 113 African-American and 67 Mexican-American cases with newly diagnosed, previously untreated lung cancer and 270 controls, frequency-matched on age, ethnicity, and sex. Mutagen sensitivity (1 chromatid break/cell after short-term bleomycin treatment) was associated with statistically significant elevated risk for lung cancer [odds ratio (OR) = 4.3; 95% confidence intervals (I = 2.37.9]. Wood dust exposure was also a significant predictor of risk (overall OR = 3.5; CI = 1.4-8.6) after controlling for smoking and mutagen sensitivity. When stratified by ethnicity, wood dust exposure was a significant risk factor for African-Americans (OR = 5.5; CI = 1.6-18.9) but not for Mexican-Americans (OR = 2.0; CI = 0.58.1). The ORs were 3.8 and 4.8 for non-small cell lung cancer in Mexican-Americans and African-Americans, respectively, but were only statistically significant for African-Americans (CI = 1.2-18.5). Stratified analysis suggested evidence of strong interactions between wood dust exposure and both mutagen sensitivity and smoking in lung cancer risk.
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M3 - Article
C2 - 8547823
AN - SCOPUS:0029114980
SN - 1055-9965
VL - 4
SP - 583
EP - 588
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 6
ER -