TY - JOUR
T1 - A changing pattern of susceptibility of Xanthomonas maltophilia to antimicrobial agents
T2 - Implications for therapy
AU - Vartivarian, S.
AU - Anaissie, E.
AU - Bodey, G.
AU - Sprigg, H.
AU - Rolston, K.
PY - 1994
Y1 - 1994
N2 - The in vitro susceptibilities of 130 Xanthomonas maltophilia isolates to 12 antibiotics-trimethoprim-sulfamethoxazole, minocycline, ticarcillin- clavulanate, ceftazidime, cefoperazone, cefoperazone-sulbactam, imipenem, ciprofloxacin, and the investigational quinolones PD 117558, PD 117596, PD 127391, and sparfloxacin-were determined by a microtiter broth dilution technique. Other than the investigational quinolones, the most active antibiotics were minocycline, trimethoprim-sulfamethoxazole, and ticarcillin- clavulanate, in order. However, the first two were not bactericidal, while about half of the isolates exhibited intermediate susceptibility to ticarcillin-clavulanate. Patterns of susceptibility to trimethoprim- sulfamethoxazole and ciprofloxacin relative to the years of isolation of these strains reflected the development of resistance to the antibiotic prophylaxis practices in the hospital. We recommend that a combination of antibiotics, such as trimethoprim-sulfamethoxazole, minocycline, and ticarcillin-clavulanate, at or close to the maximum tolerated doses be used in the treatment of serious X. maltophilia infections.
AB - The in vitro susceptibilities of 130 Xanthomonas maltophilia isolates to 12 antibiotics-trimethoprim-sulfamethoxazole, minocycline, ticarcillin- clavulanate, ceftazidime, cefoperazone, cefoperazone-sulbactam, imipenem, ciprofloxacin, and the investigational quinolones PD 117558, PD 117596, PD 127391, and sparfloxacin-were determined by a microtiter broth dilution technique. Other than the investigational quinolones, the most active antibiotics were minocycline, trimethoprim-sulfamethoxazole, and ticarcillin- clavulanate, in order. However, the first two were not bactericidal, while about half of the isolates exhibited intermediate susceptibility to ticarcillin-clavulanate. Patterns of susceptibility to trimethoprim- sulfamethoxazole and ciprofloxacin relative to the years of isolation of these strains reflected the development of resistance to the antibiotic prophylaxis practices in the hospital. We recommend that a combination of antibiotics, such as trimethoprim-sulfamethoxazole, minocycline, and ticarcillin-clavulanate, at or close to the maximum tolerated doses be used in the treatment of serious X. maltophilia infections.
UR - http://www.scopus.com/inward/record.url?scp=0028273362&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028273362&partnerID=8YFLogxK
U2 - 10.1128/AAC.38.3.624
DO - 10.1128/AAC.38.3.624
M3 - Comment/debate
C2 - 8203865
AN - SCOPUS:0028273362
SN - 0066-4804
VL - 38
SP - 624
EP - 627
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 3
ER -